Secondary Metabolites Produced by an Endophytic Fungus Pestalotiopsis microspora

  • Nat Prod Bioprospect. 2019 Dec;9(6):411-417. doi: 10.1007/s13659-019-00225-0.
G R Nalin Rathnayake  1 ,  N Savitri Kumar  1 ,  Lalith Jayasinghe  2 ,  Hiroshi Araya  3 ,  Yoshinori Fujimoto  1  3
Affiliations
  • 1. National Institute of Fundamental Studies, Hantana Road, Kandy, Sri Lanka.
  • 2. National Institute of Fundamental Studies, Hantana Road, Kandy, Sri Lanka. [email protected].
  • 3. School of Agriculture, Meiji University, Kawasaki, Kanagawa, 214-8571, Japan.
PMID: 31729648 DOI: 10.1007/s13659-019-00225-0
Abstract

An endophytic fungus Pestalotiopsis microspora isolated from the fruits of Manilkara zapota was cultured in potato dextrose broth media. Chromatographic separation of the EtOAc extract of the broth and mycelium led to the isolation of a new azaphilonoid named pitholide E (1), in addition to previously identified pitholide B (2), pitholide D (3), pestalotin (LL-P880α) (4), PC-2 (5), LL-P880β (6), tyrosol (7) and 4-oxo-4H-pyran-3-acetic acid (8). An endophytic fungus P. microspora from M. zapota and the isolation of compounds 1-5, 7 and 8 from P. microspora are reported here for the first time.

Keywords
Endophyte; Manilkara zapota; Pestalotin; Pestalotiopsis microspora; Pitholide E.
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