2. Academic Validation
  3. Oxidative Stress in Chronic Liver Disease and Portal Hypertension: Potential of DHA as Nutraceutical

Oxidative Stress in Chronic Liver Disease and Portal Hypertension: Potential of DHA as Nutraceutical

  • Nutrients. 2020 Aug 28;12(9):2627. doi: 10.3390/nu12092627.
Zoe Boyer-Diaz 1,  Paloma Morata 2,  Peio Aristu-Zabalza 1,  Albert Gibert-Ramos 3,  Jaime Bosch 3 4 5,  Jordi Gracia-Sancho 1 3 4 5
Affiliations

Affiliations

  • 1 Barcelona Liver Bioservices, 08034 Barcelona, Spain.
  • 2 BrudyTechnology, 08006 Barcelona, Spain.
  • 3 Liver Vascular Biology Research Group, IDIBAPS, 08036 Barcelona, Spain.
  • 4 CIBEREHD, 28029 Madrid, Spain.
  • 5 Hepatology, Department of Biomedical Research, University of Bern, 3012 Bern, Switzerland.
PMID: 32872239 DOI: 10.3390/nu12092627
Abstract

Chronic liver disease constitutes a growing public health issue worldwide, with no safe and effective enough treatment clinical scenarios. The present review provides an overview of the current knowledge regarding advanced chronic liver disease (ACLD), focusing on the major contributors of its pathophysiology: inflammation, oxidative stress, fibrosis and portal hypertension. We present the benefits of supplementation with docosahexaenoic acid triglycerides (TG-DHA) in other health areas as demonstrated experimentally, and explore its potential as a novel nutraceutical approach for the treatment of ACLD and portal hypertension based on published pre-clinical data.

Keywords

TG-DHA; cirrhosis; inflammation; liver fibrosis; omega-3; oxidative stress.

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