2. Academic Validation
  3. Methionine analogues as inhibitors of methionyl-tRNA synthetase

Methionine analogues as inhibitors of methionyl-tRNA synthetase

  • Bioorg Med Chem Lett. 1998 Dec 15;8(24):3511-4. doi: 10.1016/s0960-894x(98)00642-8.
J Lee 1,  M K Kang,  M W Chun,  Y J Jo,  J H Kwak,  S Kim
Affiliations

Affiliation

  • 1 Laboratory of Medicinal Chemistry, College of Pharmacy, Seoul National University, Korea.
PMID: 9934462 DOI: 10.1016/s0960-894x(98)00642-8
Abstract

A series of methionine analogues have been synthesized as inhibitors of methionyl-tRNA synthetase and evaluated for their inhibitory activities of E. coli methionyl-tRNA synthetase and Bacterial growth. Among them, L-methionine hydroxamate 20 has proved to be the best inhibitor of the Enzyme with Ki = 19 microM and showed a growth inhibition against E.coli JM 109, P. vulganis 6059 and C. freundii 8090.

Figures
Products