Methionine analogues as inhibitors of methionyl-tRNA synthetase

  • Bioorg Med Chem Lett. 1998 Dec 15;8(24):3511-4. doi: 10.1016/s0960-894x(98)00642-8.
J Lee  1 ,  M K Kang ,  M W Chun ,  Y J Jo ,  J H Kwak ,  S Kim
Affiliations
  • 1. Laboratory of Medicinal Chemistry, College of Pharmacy, Seoul National University, Korea.
PMID: 9934462 DOI: 10.1016/s0960-894x(98)00642-8
Abstract

A series of methionine analogues have been synthesized as inhibitors of methionyl-tRNA synthetase and evaluated for their inhibitory activities of E. coli methionyl-tRNA synthetase and Bacterial growth. Among them, L-methionine hydroxamate 20 has proved to be the best inhibitor of the enzyme with Ki = 19 microM and showed a growth inhibition against E.coli JM 109, P. vulganis 6059 and C. freundii 8090.

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