1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. ML418

ML418 

Cat. No.: HY-122697 Purity: 99.19%
Handling Instructions

ML418 is the first potent, selective and CNS penetrating blocker of Kir7.1 potassium channel (IC50, 310 nM), which also potently inhibits Kir6.2/SUR1, and exhibits superior selectivity over other Kir channels.

For research use only. We do not sell to patients.

ML418 Chemical Structure

ML418 Chemical Structure

CAS No. : 1928763-08-9

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Free Sample (0.5-1 mg)   Apply Now  
5 mg USD 140 In-stock
Estimated Time of Arrival: December 31
10 mg USD 230 In-stock
Estimated Time of Arrival: December 31
50 mg USD 600 In-stock
Estimated Time of Arrival: December 31
100 mg USD 950 In-stock
Estimated Time of Arrival: December 31
250 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

ML418 is the first potent, selective and CNS penetrating blocker of Kir7.1 potassium channel (IC50, 310 nM), which also potently inhibits Kir6.2/SUR1, and exhibits superior selectivity over other Kir channels[1].

Molecular Weight

377.87

Formula

C₁₉H₂₄ClN₃O₃

CAS No.

1928763-08-9

SMILES

O=C(OC(C)C)NC1CCN(CC2=CC(Cl)=C3C=CC=NC3=C2O)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (66.16 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6464 mL 13.2321 mL 26.4641 mL
5 mM 0.5293 mL 2.6464 mL 5.2928 mL
10 mM 0.2646 mL 1.3232 mL 2.6464 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

ML418ML 418ML-418Potassium ChannelKcsAInhibitorinhibitorinhibit

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