GCN1 - GCN1 activator of EIF2AK4 Gene

Also Known as GCN1L; GCN1L1; PRIC295

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10985

About GCN1

Cytogenetic location: 12q24.23 Genomic coordinates (GRCh38): 12:120,127,202-120,194,715 (from NCBI)

This gene has 9 transcripts (splice variants), 205 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 14.2), thyroid (RPKM 12.3) and 25 other tissues.

Summary

Enables RNA binding activity and Cadherin binding activity. Predicted to be involved in cellular response to leucine starvation and positive regulation of transcription from RNA polymerase II promoter in response to stress. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

GCN1 Products (1)

mRNA Protein Name
NM_006836.2 NP_006827.1 eIF-2-alpha kinase activator GCN1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
36638793 GOA
enables stalled ribosome sensor activity IDA
IDA: Inferred from direct assay
36638793 GOA
Biological Process GO Annotation Evidence References Source
involved in protein-RNA covalent cross-linking repair IDA
IDA: Inferred from direct assay
37951215 GOA
involved in rescue of stalled ribosome IDA
IDA: Inferred from direct assay
36638793 GOA
Cellular Component GO Annotation Evidence References Source
is active in cytosolic ribosome IDA
IDA: Inferred from direct assay
36638793 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GCN1 Protein Structure

Gcn1_N

Gcn1_N: Domain of unknown function (DUF3554) (377 - 706)

HEAT_2

HEAT_2: HEAT repeats (1499 - 1591)

  • 0
  • 500
  • 1000
  • 1500
  • 2000
  • 2500
  • 2671 a.a.
Protein Preferred Names Protein Names

eIF-2-alpha kinase activator GCN1

  • GCN1 (general control of amino-acid synthesis 1, yeast)-like 1

Related Diseases

Diseases Alias
Ogden Syndrome

  • OGDNS

  • N-Terminal Acetyltransferase Deficiency

  • NATD

  • N-Alpha-Acetyltransferase

  • X-Linked Malformation And Infantile Lethality Syndrome

  • Premature Aging Appearance-Developmental Delay-Cardiac Arrhythmia Syndrome
Myopathy, Centronuclear, 2

  • Myopathy, Centronuclear, Autosomal Recessive

  • Autosomal Recessive Centronuclear Myopathy

  • CNM2

  • Centronuclear Myopathy 2

  • Ar-Cnm

  • Myotubular Myopathy, Autosomal Recessive

  • Autosomal Recessive Myotubular Myopathy

  • Centronuclear Myopathy Autosomal Recessive

  • Myopathy, Centronuclear, Type 2
Hydrarthrosis
Neuroblastoma

  • Nb

  • Neuroblastoma, Susceptibility To

  • Neuroblastomas

  • Central Neuroblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W319647 GCN2 activator-1 Inhibitor 99.69% Unkown
HY-177569 NVS1.1 Degrader / Unkown
HY-177757 NVS2.1 Degrader 99.9% Unkown
HY-RS05337 GCN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GCN1 RGD RGD:1593434
Canis familiaris GCN1 VGNC VGNC:41151
Mus musculus GCN1 MGD MGI:2444248
Macaca mulatta GCN1 VGNC VGNC:72905
Bos taurus GCN1 VGNC VGNC:29292
Felis catus GCN1 VGNC VGNC:62496
Others GCN1 NCBI