COPS5 - COP9 signalosome subunit 5 Gene

Also Known as CSN5; JAB1; SGN5; MOV-34

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10987

About COPS5

Cytogenetic location: 8q13.1 Genomic coordinates (GRCh38): 8:67,043,079-67,062,133 (from NCBI)

This gene has 13 transcripts (splice variants), 224 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 37.3), heart (RPKM 32.6) and 25 other tissues.

Summary

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S Proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]

COPS5 Products (1)

mRNA	Protein	Name
NM_006837.3	NP_006828.2	COP9 signalosome complex subunit 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables metal-dependent deubiquitinase activity	IDA IDA: Inferred from direct assay	19246649	GOA
enables metallopeptidase activity	IMP IMP: Inferred from mutant phenotype	19214193	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12082530	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in exosomal secretion	IDA IDA: Inferred from direct assay	19246649	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	20978819	GOA
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	20978819	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16410250	GOA
involved in protein deneddylation	IDA IDA: Inferred from direct assay	19141280	GOA
involved in protein deneddylation	IMP IMP: Inferred from mutant phenotype	19214193	GOA
involved in regulation of IRE1-mediated unfolded protein response	IMP IMP: Inferred from mutant phenotype	15234121	GOA
involved in regulation of JNK cascade	IDA IDA: Inferred from direct assay	16410250	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of COP9 signalosome	IDA IDA: Inferred from direct assay	18850735	GOA
part of COP9 signalosome	IPI IPI: Inferred from physical interaction	25043011	GOA
located in chromatin	IDA IDA: Inferred from direct assay	20978819	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16300740	GOA
located in cytosol	IDA IDA: Inferred from direct assay	20978819	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16300740	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16300740	GOA
located in synaptic vesicle	IDA IDA: Inferred from direct assay	21102408	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COPS5 Protein Structure

JAB

0
100
200
300
334 a.a.

Protein Preferred Names	Protein Names
COP9 signalosome complex subunit 5	38 kDa Mov34 homolog

COPS5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	COPS5	Q92905	RNF20	Homo sapiens	Q5VTR2	Anti Tag CoIP	19214193
Intra	COPS5	Q92905	OPRM1	Homo sapiens	P35372	Y2H	23840749
Intra	COPS5	Q92905	OPRM1	Homo sapiens	P35372	Anti Tag CoIP	23840749
Intra	COPS5	Q92905	OPRM1	Homo sapiens	P35372	Pull Down	23840749
Intra	COPS5	Q92905	BRSK2	Homo sapiens	Q8IWQ3	Pull Down	22609399
Intra	COPS5	Q92905	BRSK2	Homo sapiens	Q8IWQ3	Confocal	22609399
Intra	COPS5	Q92905	BRSK2	Homo sapiens	Q8IWQ3	Anti Bait CoIP	22609399
Intra	COPS5	Q92905	BRSK2	Homo sapiens	Q8IWQ3	Y2H	22609399
Intra	COPS5	Q92905	BRSK2	Homo sapiens	Q8IWQ3	Anti Tag CoIP	22609399
Intra	COPS5	Q92905	COPS3	Homo sapiens	Q9UNS2	TAP	18850735
Intra	COPS5	Q92905	COPS3	Homo sapiens	Q9UNS2	Anti Tag CoIP	19615732
Intra	COPS5	Q92905	COPS3	Homo sapiens	Q9UNS2	Anti Tag CoIP	20399188
Intra	COPS5	Q92905	COPS3	Homo sapiens	Q9UNS2	TAP	21145461
Intra	COPS5	Q92905	COPS3	Homo sapiens	Q9UNS2	Anti Tag CoIP	33961781
Intra	COPS5	Q92905	COPS3	Homo sapiens	Q9UNS2	Anti Tag CoIP	28514442
Intra	COPS5	Q92905	SMAD7	Homo sapiens	O15105	Confocal	14993265
Intra	COPS5	Q92905	SMAD7	Homo sapiens	O15105	Pull Down	14993265
Intra	COPS5	Q92905	SMAD7	Homo sapiens	O15105	Anti Tag CoIP	14993265
Intra	COPS5	Q92905	SMAD7	Homo sapiens	O15105	Y2H	14993265
Intra	COPS5	Q92905	F2RL1	Homo sapiens	P55085	Y2H	16410250
Intra	COPS5	Q92905	F2RL1	Homo sapiens	P55085	Anti Bait CoIP	16410250
Intra	COPS5	Q92905	F2RL1	Homo sapiens	P55085	Confocal	16410250
Intra	COPS5	Q92905	CUL3	Homo sapiens	Q13618	Anti Tag CoIP	33961781
Intra	COPS5	Q92905	CUL3	Homo sapiens	Q13618	TAP	21145461
Intra	COPS5	Q92905	CUL3	Homo sapiens	Q13618	TAP	18850735
Intra	COPS5	Q92905	CUL3	Homo sapiens	Q13618	Anti Tag CoIP	19615732
Intra	COPS5	Q92905	COPS6	Homo sapiens	Q7L5N1	Anti Tag CoIP	20399188
Intra	COPS5	Q92905	COPS6	Homo sapiens	Q7L5N1	Pull Down	25043011
Intra	COPS5	Q92905	COPS6	Homo sapiens	Q7L5N1	TAP	18850735
Intra	COPS5	Q92905	COPS6	Homo sapiens	Q7L5N1	Anti Tag CoIP	19615732
Intra	COPS5	Q92905	COPS6	Homo sapiens	Q7L5N1	TAP	21145461
Intra	COPS5	Q92905	CDKN1B	Homo sapiens	P46527	Pull Down	15480426
Intra	COPS5	Q92905	TXN	Homo sapiens	P10599	Pull Down	15480426
Intra	COPS5	Q92905	TXN	Homo sapiens	P10599	TAP	21145461
Intra	COPS5	Q92905	TXN	Homo sapiens	P10599	Anti Bait CoIP	15480426
Intra	COPS5	Q92905	TXN	Homo sapiens	P10599	FRET	15480426
Intra	COPS5	Q92905	UCHL1	Homo sapiens	P09936	Y2H	12082530
Intra	COPS5	Q92905	UCHL1	Homo sapiens	P09936	IF	12082530
Intra	COPS5	Q92905	UCHL1	Homo sapiens	P09936	Anti Bait CoIP	12082530
Intra	COPS5	Q92905	MINDY3	Homo sapiens	Q9H8M7	Anti Tag CoIP	21499297
Intra	COPS5	Q92905	MINDY3	Homo sapiens	Q9H8M7	Y2H	21499297
Intra	COPS5	Q92905	GPS1	Homo sapiens	Q13098	Anti Tag CoIP	19615732
Intra	COPS5	Q92905	GPS1	Homo sapiens	Q13098	Anti Tag CoIP	20399188
Intra	COPS5	Q92905	GPS1	Homo sapiens	Q13098	TAP	21145461
Intra	COPS5	Q92905	GPS1	Homo sapiens	Q13098	TAP	18850735
Intra	COPS5	Q92905	GPS1	Homo sapiens	Q13098	Anti Tag CoIP	33961781
Intra	COPS5	Q92905	GTPBP3	Homo sapiens	Q969Y2	Validated Y2H	32296183
Intra	COPS5	Q92905	CCNDBP1	Homo sapiens	O95273	Confocal	15887118

Cross: Cross-species interaction Intra: Intraspecies interaction

COPS5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83414	JAB1 Antibody (YA3159)	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Maxillary Sinus Adenocarcinoma	Adenocarcinoma Of Maxillary Sinus Adenocarcinoma Of The Maxillary Sinus
Xeroderma Pigmentosum, Complementation Group E	Xeroderma Pigmentosum V Xp5 Xeroderma Pigmentosum, Group E, Ddb-Negative Subtype Xpe Xp, Group E Xeroderma Pigmentosum, Type 5 Xeroderma Pigmentosum Complementation Group E XP-E Xp Group E
Cockayne Syndrome	Cockayne'S Syndrome Dwarfism-Retinal Atrophy-Deafness Syndrome Neill-Dingwall Syndrome Progeria-Like Syndrome Progeroid Nanism Cs
Autosomal Dominant Cerebellar Ataxia	Spinocerebellar Ataxia Adca Pierre Marie Cerebellar Ataxia Ataxia, Spinocerebellar Sca Autosomal Dominant Spinocerebellar Ataxia Spinocerebellar Ataxias
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Hereditary Ataxia	Sca Spinocerebellar Ataxia Ataxias Hereditary Ataxias, Hereditary
Cerebellar Disease	Cerebellar Diseases Cerebellar Dysfunction Cerebellar Abnormality Cerebellar Disorders
Machado-Joseph Disease	SCA3 MJD Spinocerebellar Ataxia 3 Azorean Disease Spinocerebellar Ataxia Type 3 Spinocerebellar Atrophy Azorean Neurologic Disease Spinopontine Atrophy Nigrospinodentatal Degeneration Spinocerebellar Atrophy Iii Spinocerebellar Atrophy Type 3 Azorean Ataxia Azorean Disease Of The Nervous System Machado Disease Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia Disease, Machado-Joseph Ataxia, Spinocerebellar
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03030	COPS5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19669	Cops5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26162	Cops5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	COPS5	VGNC	VGNC:61090
Mus musculus	COPS5	MGD	MGI:1349415
Macaca mulatta	COPS5	VGNC	VGNC:71317
Bos taurus	COPS5	VGNC	VGNC:27602
Rattus norvegicus	COPS5	RGD	RGD:1310301
Canis familiaris	COPS5	VGNC	VGNC:54110
Others	COPS5	NCBI