Pou5f1 - POU class 5 homeobox 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 294562

About Pou5f1

Primary_assembly 20: 3,223,129-3,227,891 reverse strand.mRatBN7.2:CM026993.1

This gene has 1 transcript (splice variant), 331 orthologues, 16 paralogues and is associated with 12 phenotypes. Biased expression in Liver (RPKM 6.5), Thymus (RPKM 3.2) and 8 other tissues.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; protein domain specific binding activity; and sequence-specific DNA binding activity. Involved in regulation of transcription, DNA-templated and response to cytokine. Located in nucleus. Human ortholog(s) of this gene implicated in embryonal carcinoma and seminoma. Orthologous to several human genes including POU5F1 (POU class 5 homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Pou5f1 Products (1)

mRNA Protein Name
NM_001009178.2 NP_001009178.1 POU domain, class 5, transcription factor 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
12637543 RGD
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
9196379 RGD
enables HMG box domain binding IDA
IDA: Inferred from direct assay
12637543 RGD
enables POU domain binding IDA
IDA: Inferred from direct assay
12637543 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12637543 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
9196379 RGD
Biological Process GO Annotation Evidence References Source
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
9196379 RGD
involved in response to benzoic acid IEP
IEP: Inferred from expression pattern
30476341 RGD
involved in response to cytokine IEP
IEP: Inferred from expression pattern
10896787 RGD
involved in response to retinoic acid IEP
IEP: Inferred from expression pattern
30476341 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pou5f1 Protein Structure

POU

POU: smart00352 (130 - 204)

Homeobox

Homeobox: pfam00046 (225 - 278)

  • 0
  • 100
  • 200
  • 300
  • 352 a.a.
Protein Preferred Names Protein Names

POU domain, class 5, transcription factor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10907 POU5F1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10908 Pou5f1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-168566 EV206 Inhibitor 99.62% Unkown
HY-RS10909 Pou5f1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10910 POU5F1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174544 Human POU5F1 mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pou5f1 NCBI NCBI:5460