POU5F1 - POU class 5 homeobox 1 Gene

Also Known as OCT3; OCT4; OTF3; OTF4; OTF-3; Oct-3; Oct-4; Oct3/4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5460

About POU5F1

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,164,337-31,170,682 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 319 orthologues, 17 paralogues and is associated with 50 phenotypes. Broad expression in lung (RPKM 1.3), small intestine (RPKM 1.2) and 21 other tissues.

Summary

This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013]

POU5F1 Products (5)

mRNA	Protein	Name
NM_001285986.2	NP_001272915.1	POU domain, class 5, transcription factor 1 isoform 4
NM_001173531.3	NP_001167002.1	POU domain, class 5, transcription factor 1 isoform 2
NM_203289.6	NP_976034.4	POU domain, class 5, transcription factor 1 isoform 2
NM_001285987.1	NP_001272916.1	POU domain, class 5, transcription factor 1 isoform 3
NM_002701.6	NP_002692.2	POU domain, class 5, transcription factor 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	16153702	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	16153702	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	19409607	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	19736317	GOA
enables miRNA binding	IDA IDA: Inferred from direct assay	18710938	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11891324	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20713518	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	19409607	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	19274063	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in BMP signaling pathway	IDA IDA: Inferred from direct assay	19736317	GOA
involved in cardiac cell fate determination	IDA IDA: Inferred from direct assay	19736317	GOA
involved in cell fate commitment involved in formation of primary germ layer	IMP IMP: Inferred from mutant phenotype	19736317	GOA
acts upstream of or within endodermal cell fate specification	IDA IDA: Inferred from direct assay	20713518	GOA
involved in endodermal-mesodermal cell signaling	IDA IDA: Inferred from direct assay	19736317	GOA
involved in heart induction	IMP IMP: Inferred from mutant phenotype	19736317	GOA
involved in negative regulation of miRNA transcription	IDA IDA: Inferred from direct assay	19409607	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19409607	GOA
involved in positive regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	19736317	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20713518	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19736317	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16153702	GOA
involved in regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18388306	GOA
involved in response to wounding	IEP IEP: Inferred from expression pattern	17982423	GOA
involved in somatic stem cell population maintenance	IDA IDA: Inferred from direct assay	19409607	GOA
involved in somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	18388306	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18281244	GOA
located in cytosol	IDA IDA: Inferred from direct assay	18000303	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	20458727	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18000303	GOA
part of transcription regulator complex	IDA IDA: Inferred from direct assay	19736317	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POU5F1 Protein Structure

Pou

Homeobox

0
100
200
300
360 a.a.

Protein Preferred Names	Protein Names
POU domain, class 5, transcription factor 1	POU domain transcription factor OCT4 POU-type homeodomain-containing DNA-binding protein octamer-binding protein 3 octamer-binding protein 4 octamer-binding transcription factor 3

POU5F1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	POU5F1	Q01860	FOXD3	Homo sapiens	Q9UJU5	Pull Down	11891324
Intra	POU5F1	Q01860	FOXD3	Homo sapiens	Q9UJU5	CoIP	11891324
Intra	POU5F1	Q01860	SOX2	Homo sapiens	P48431	Anti Bait CoIP	19736317
Cross	POU5F1	Q01860	Hmgb1	Mus musculus	P63158	Competition Binding	11099378
Intra	POU5F1	Q01860	WWP2	Homo sapiens	O00308	Anti Tag CoIP	19274063
Intra	POU5F1	Q01860	WWP2	Homo sapiens	O00308	Anti Bait CoIP	19274063

Cross: Cross-species interaction Intra: Intraspecies interaction

POU5F1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80440	Oct-4 Antibody (YA837)	WB, ICC/IF	Human, Mouse
HY-P80770	Oct-4 Antibody	WB, IHC-P, ICC/IF, IP, ChIP	Human, Mouse
HY-P84462	Oct-4 Antibody (YA4159)	WB, ICC/IF, FC, ELISA	Human
HY-P84462A	Oct-4 Antibody (YA4159)(PBS only)	WB, ICC/IF, FC, ELISA	Human
HY-P84463	Oct-4 Antibody (YA4160)	IHC-P, FC, ELISA	Human
HY-P84463A	Oct-4 Antibody (YA4160)(PBS only)	IHC-P, FC, ELISA	Human
HY-P85304	Oct-3/4 Antibody (YA4996)	WB; ICC/IF

Related Diseases

Diseases	Alias
Intratubular Embryonal Carcinoma	Stage 0 Testicular Embryonal Carcinoma
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Tyrosinemia	Hypertyrosinemia Tyrosinemias Hereditary Tyrosinemia Hypertyrosinaemia Tyrosinaemia Hereditary Hypertyrosinemia
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Epilepsy, Idiopathic Generalized 17	Febrile Seizures, Familial, 2 EIG17 Familial Febrile Seizures 2 FEB2 Epilepsy, Idiopathic Generalized, Susceptibility To, 17 Familial Febrile Convulsions 2 Convulsions, Familial Febrile, 2
Spermatogenic Failure, Y-Linked, 1	SPGFY1 Sertoli Cell-Only Syndrome, Y-Linked Y-Linked Spermatogenic Failure 1 Sertoli Cell-Only Syndrome, Type I Type I Sertoli Cell-Only Syndrome Y-Linked Sertoli Cell-Only Syndrome
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Ovarian Gonadoblastoma
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Adhesions Of Uterus	Intrauterine Adhesions Intrauterine Synechiae Band Of Uterus Asherman Syndrome Internal Adhesion Of Uterus Internal Band Of Uterus
Dysgerminoma Of Ovary	Ovarian Dysgerminoma Malignant Dysgerminomatous Germ Cell Tumour Of Ovary Dysgerminoma, Unspecified Site, Female
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma Primitive Neuroectodermal Tumor ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Ewing Family Of Tumors Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Parkinson Disease 17	PARK17 Parkinson'S Disease 17 Autosomal Dominant Parkinson Disease 17 Parkinson Disease, Type 17
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
Seminoma	Seminoma, Pure
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Endodermal Sinus Tumor	Yolk Sac Tumor Endodermal Sinus Tumour Hepatoid Yolk Sac Tumour Infantile Embryonal Carcinoma Yolk Sac Neoplasm Yolk Sac Tumour
Testicular Disease	Testicular Dysfunction Testicular Diseases Disorder Of Testis Testis Disorder Testicular Disorders
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Ocular Cancer	Eye Carcinoma Eye Neoplasm Eye Cancer Eye Neoplasms Malignant Eye Neoplasm Neoplasm Of Eye Neoplasm Of Eye Proper Ocular Tumor Carcinoma Of Eye Ocular Carcinoma Malignant Tumor Of Eye
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Glioblastoma Classical Subtype
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Diencephalic Astrocytoma	Astrocytoma Of Diencephalon
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Childhood Testicular Germ Cell Tumor	Paediatric Testicular Germ Cell Neoplasm Paediatric Testicular Germ Cell Tumour Pediatric Testicular Germ Cell Neoplasm Pediatric Testicular Germ Cell Tumor Testicular Germ Cell Tumor, Pediatric
Glycogen Storage Disease	Glycogenosis Glycogenoses Gsd Storage Disease, Glycogen Gsd - [Glycogen Storage Disease] Glycogen Thesaurismosis Diffuse Glycogenosis Generalised Glycogen Storage Disease Generalised Glycogenosis Generalised Glycogen Storage Disease Of Infants Glycogen Synthase Deficiency
Cryptorchidism, Unilateral Or Bilateral	Cryptorchidism Undescended Testicle Undescended Testis Cryptorchism Undescended Testicles CRYPTO Impaired Testicular Descent Cryptosporidiosis Retained Testis Unilateral Cryptorchidism Unilateral Undescended Testis Nondescent Unilateral Testicle Unilateral Cryptorchism Ectopic Testis, Unilateral Bilateral Cryptorchidism Bilateral Cryptorchism Bilateral Nondescent Testicle Bilateral Undescended Testes Bilateral Ectopic Testes
Germ Cell Cancer	Malignant Germ Cell Tumor Germ Cell Neoplasm Germ Cell Tumour Malignant Tumor Of The Germ Cell Neoplasms Germ Cell Neoplasms, Germ Cell And Embryonal Malignant Germ Cell Neoplasm
Macular Degeneration, Age-Related, 7	Age Related Macular Degeneration 7 ARMD7 Macular Degeneration, Age-Related, Neovascular Type Susceptibility To Neovascular Type Of Age-Related Macular Degeneration Macular Degeneration, Age-Related, Type 7
Mature Teratoma	Dermoid Cyst Benign Teratoma
Testicular Cancer	Testis Cancer Testicular Carcinoma Testicular Neoplasms Malignant Neoplasm Of Testis Childhood Neoplasm Of The Testis Neoplasm Of Testis Pediatric Testicular Neoplasm Testicular Tumor Testis Neoplasm Testicular Tumors Testicular Neoplasm Testicular Malignant Germ Cell Tumor Childhood Testicular Neoplasm Carcinoma Of The Testis Cancer Of Testis Malignant Neoplasm Of Testis, Nos Malignant Neoplasm Of Testis, Unspecified Malignant Tumour Of Testis Testicle Cancer Primary Malignant Neoplasm Of Testis
Gonadoblastoma	GBY
Turner Syndrome	Monosomy X Gonadal Dysgenesis Turner Type Ullrich-Turner Syndrome Bonnevie-Ullrich Syndrome Karyotype 45, X Genital Dwarfism, Turner Type Gonadal Dysgenesis Turner'S Syndrome Gonadal Dysgenesis - Turner Monosomy X Syndrome Xo Syndrome Genital Dwarfism 45, X Syndrome Bonnevie-Ulrich Syndrome Chromosome X Monosomy X Schereshevkii Turner Syndrome Turner Varny Syndrome 45,X Ts 45,X Syndrome 45,X/46,Xx Syndrome Turners Syndrome Gonadal Dysgenesis, 45,X X0 Syndrome
Methylmalonic Aciduria And Homocystinuria, Cblx Type	Mental Retardation, X-Linked 3 Methylmalonic Acidemia With Homocystinuria, Type Cblx MAHCX Intellectual Developmental Disorder, X-Linked 3 Xlid3 Mrx3 Methylmalonic Acidemia And Homocysteinemia Cblx Type Combined Defect In Adenosylcobalamin And Methylcobalamin Synthesis, Type Cblx Methylmalonic Aciduria With Homocystinuria, Type Cblx Methylmalonic Acidemia And Homocysteinemia, Cblx Type Methylmalonic Aciduria And Homocysteinemia, Cblx Type Mental Retardation, X-Linked, Type 3
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Germinoma
Testicular Germ Cell Cancer	Germ Cell Tumor Of Testis Testicular Germ Cell Tumor Testicular Germ Cell Neoplasm Testicular Malignant Germ Cell Tumor
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Ovarian Primitive Germ Cell Tumor
Hard Palate Cancer	Malignant Neoplasm Of Hard Palate Malignant Tumor Of Hard Palate Malignant Tumour Of Hard Palate
Ovarian Embryonal Carcinoma	Embryonal Carcinoma Of Ovary Embryonal Carcinoma Of The Ovary
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism
Germ Cell And Embryonal Cancer	Germ Cell And Embryonal Neoplasm
Teratoma	Teratomas
Brain Germinoma	Intracranial Germinoma Germinoma Of The Brain
Ovarian Endodermal Sinus Tumor	Endodermal Sinus Tumor Of Ovary Ovarian Yolk Sac Tumor Endodermal Sinus Tumour Of Ovary Ovarian Endodermal Sinus Tumour Ovarian Yolk Sac Tumour
Spermatocytoma	Spermatocytic Seminoma
Gonadal Dysgenesis	Gonadal Dysgenesis Syndrome Turner Syndrome
Pineoblastoma	Pineal Pnet Pinealoma Pineal Gland Neoplasm Pineocytoma Tumor Of The Pineal Region
Malignant Teratoma	Immature Teratoma Malignant Extragonadal Teratoma Primary Malignant Extragonadal Teratoma Teratoma, Malignant, Nos Teratoma, Malignant Immature Extragonadal Teratoma
Mixed Germ Cell Cancer	Mixed Germ Cell Tumor Mixed Germ Cell Neoplasm Mixed Germ Cell Tumour Mixed Teratoma And Seminoma
Ovarian Germ Cell Cancer	Ovarian Germ Cell Tumor Malignant Germ Cell Tumor Of Ovary Germ Cell Neoplasm Of Ovary Germ Cell Tumor Of Ovary Mogct Malignant Ovarian Germ Cell Tumor Malignant Ovarian Germ Cell Neoplasm
Embryonal Carcinoma	Embryonal Neoplasm Embryonal Cancer Primary Extragonadal Embryonal Carcinoma Embryo Neoplasm Carcinoma Embryonal Cancer Embryonal Carcinoma, Embryonal Extragonadal Embryonal Carcinoma Cancer, Embryonal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10907	POU5F1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10908	Pou5f1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-168566	EV206	Inhibitor	99.62%	Unkown
HY-RS10909	Pou5f1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10910	POU5F1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174544	Human POU5F1 mRNA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	POU5F1	MGD	MGI:101893
Rattus norvegicus	POU5F1	RGD	RGD:1359491
Others	POU5F1	NCBI