RNASET2 - ribonuclease T2 Gene

Also Known as RNASE6PL; bA514O12.3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8635

About RNASET2

Cytogenetic location: 6q27 Genomic coordinates (GRCh38): 6:166,922,113-166,956,550 (from NCBI)

This gene has 22 transcripts (splice variants), 203 orthologues and is associated with 3 phenotypes. Broad expression in spleen (RPKM 93.0), colon (RPKM 39.0) and 24 other tissues.

Summary

This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. [provided by RefSeq, Jul 2008]

RNASET2 Products (1)

mRNA Protein Name
NM_003730.6 NP_003721.2 ribonuclease T2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA nuclease activity IDA
IDA: Inferred from direct assay
22735700 GOA
Biological Process GO Annotation Evidence References Source
involved in RNA catabolic process IDA
IDA: Inferred from direct assay
22735700 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum lumen IDA
IDA: Inferred from direct assay
16620762 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
16620762 GOA
located in lysosome IDA
IDA: Inferred from direct assay
16620762 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNASET2 Protein Structure

Ribonuclease_T2

Ribonuclease_T2: Ribonuclease T2 family (35 - 214)

  • 0
  • 100
  • 200
  • 256 a.a.
Protein Preferred Names Protein Names

ribonuclease T2

  • ribonuclease 6

Recombinant RNASET2 Proteins

Cat. No. Product Name Accession Purity
HY-P71015 RNASET2 Protein, Human (HEK293, His) O00584 (D25-H256) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P76006 RNASET2 Protein, Human (sf9, His) O00584 (D25-H256) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Leukoencephalopathy, Cystic, Without Megalencephaly

  • Cystic Leukoencephalopathy Without Megalencephaly

  • Rnaset2-Deficient Cystic Leukoencephalopathy

  • Rnase T2-Deficient Leukoencephalopathy

  • Clwm

  • Leukoencephalopathy With Bilateral Anterior Temporal Lobe Cysts

  • Infantile-Onset Rnaset2 Deficient Cystic Leukoencephalopathy

  • Lbatc

  • LCWM
Pseudo-Torch Syndrome 1

  • Pseudo-Torch Syndrome

  • Band-Like Calcification With Simplified Gyration And Polymicrogyria

  • Blcpmg

  • PTORCH1

  • Baraitser-Brett-Piesowicz Syndrome

  • Baraitser-Reardon Syndrome

  • Bilateral Band-Like Calcification With Polymicrogyria

  • Blc-Pmg

  • Microcephaly-Intracranial Calcification-Intellectual Disability Syndrome

  • Congenital Intrauterine Infection-Like Syndrome

  • Baraitser Brett Piesowicz Syndrome

  • Microcephaly - Intracranial Calcification - Intellectual Disability
Megalencephaly

  • Macroencephaly

  • Macrencephaly
Aicardi-Goutieres Syndrome

  • Aicardi Goutieres Syndrome

  • Cree Encephalitis

  • Aicardi-Goutières Syndrome

  • Encephalopathy With Basal Ganglia Calcification

  • Ags

  • Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

  • Pseudotoxoplasmosis Syndrome

  • Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

  • Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

  • Aicardi-Goutieres Syndrome 1
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12030 RNASET2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26338 Rnaset2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus RNASET2 VGNC VGNC:102504
Rattus norvegicus RNASET2 RGD RGD:1309918
Macaca mulatta RNASET2 VGNC VGNC:99439
Others RNASET2 NCBI