IER5 - immediate early response 5 Gene

Also Known as SBBI48

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51278

About IER5

Cytogenetic location: 1q25.3 Genomic coordinates (GRCh38): 1:181,088,700-181,092,900 (from NCBI)

This gene has 1 transcript (splice variant), 116 orthologues and 2 paralogues.

Summary

This gene encodes a protein that is similar to Other immediate early response proteins. In the mouse, a similar gene may play an important role in mediating the cellular response to mitogenic signals. Studies in rats found the expression of a similar gene to be increased after waking and sleep deprivation. [provided by RefSeq, Jul 2008]

IER5 Products (1)

mRNA Protein Name
NM_016545.5 NP_057629.2 immediate early response gene 5 protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IDA
IDA: Inferred from direct assay
26496226 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
26496226 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25816751 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to heat IDA
IDA: Inferred from direct assay
25816751 GOA
involved in positive regulation of cellular response to heat IMP
IMP: Inferred from mutant phenotype
26496226 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
25816751 GOA
involved in regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
26496226 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
25816751 GOA
located in nucleus IDA
IDA: Inferred from direct assay
25816751 GOA
part of protein phosphatase type 2A complex IDA
IDA: Inferred from direct assay
25816751 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IER5 Protein Structure

IER

IER: Immediate early response protein (IER) (1 - 327)

  • 0
  • 100
  • 200
  • 300
  • 327 a.a.
Protein Preferred Names Protein Names

immediate early response gene 5 protein

IER5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IER5 Q5VY09 MINK1 Homo sapiens Q8N4C8-4
Pull Down
26496226
Intra
IER5 Q5VY09 PPP2CA Homo sapiens P67775
Pull Down
26496226
Intra
IER5 Q5VY09 HSF1 Homo sapiens Q00613
Pull Down
26496226
Intra
IER5 Q5VY09 IER5 Homo sapiens Q5VY09
Pull Down
26496226
Intra
IER5 Q5VY09 RPS6KB1 Homo sapiens P23443
Pull Down
26496226
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06550 IER5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06551 IER5L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22205 Ier5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28727 Ier5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus IER5 VGNC VGNC:30040
Macaca mulatta IER5 VGNC VGNC:73561
Mus musculus IER5 MGD MGI:1337072
Rattus norvegicus IER5 RGD RGD:69252
Felis catus IER5 VGNC VGNC:107880
Canis familiaris IER5 VGNC VGNC:55742
Others IER5 NCBI