SLC39A10 - solute carrier family 39 member 10 Gene

Also Known as ZIP10; LZT-Hs2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57181

About SLC39A10

Cytogenetic location: 2q32.3 Genomic coordinates (GRCh38): 2:195,613,029-195,737,700 (from NCBI)

This gene has 9 transcripts (splice variants), 185 orthologues and 6 paralogues. Broad expression in thyroid (RPKM 12.9), brain (RPKM 12.5) and 21 other tissues.

Summary

Zinc is an essential cofactor for hundreds of Enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A10 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]

SLC39A10 Products (2)

mRNA Protein Name
NM_001127257.2 NP_001120729.1 zinc transporter ZIP10 precursor
NM_020342.3 NP_065075.1 zinc transporter ZIP10 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
27274087 GOA
enables zinc ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
27274087 GOA
Biological Process GO Annotation Evidence References Source
involved in epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
27274087 GOA
involved in zinc ion transmembrane transport IDA
IDA: Inferred from direct assay
27274087 GOA
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
30520657 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
27274087 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC39A10 Protein Structure

Zip

Zip: ZIP Zinc transporter (405 - 819)

  • 0
  • 200
  • 400
  • 600
  • 831 a.a.
Protein Preferred Names Protein Names

zinc transporter ZIP10

  • ZIP-10

Related Diseases

Diseases Alias
Acrodermatitis Enteropathica, Zinc-Deficiency Type

  • Acrodermatitis Enteropathica

  • AEZ

  • Enteropathica

  • Brandt Syndrome

  • Ae

  • Acrodermatitis Enteropathica Zinc Deficiency Type

  • Danbolt-Cross Syndrome

  • Acrodermatitis Enteropathica, Zinc Deficiency Type

  • Inherited Zinc Deficiency

  • Acrodermatitis Enteropathica, Zinc Deficiency

  • Danbolt-Closs Syndrome

  • Primary Zinc Malabsorption Syndrome
Ehlers-Danlos Syndrome, Spondylodysplastic Type, 3

  • Spondylocheirodysplasia, Ehlers-Danlos Syndrome-Like

  • Scd-Eds

  • EDSSPD3

  • Ehlers-Danlos Syndrome Spondylodysplastic Type 3

  • Ehlers-Danlos Syndrome, Spondylocheirodysplastic Type

  • Slc39a13-Related Spondylodysplastic Ehlers-Danlos Syndrome

  • Slc39a13-Related Speds

  • Slc39a13-Related Spondylodysplastic Eds

  • Spondylocheirodysplastic Ehlers-Danlos Syndrome

  • Speds-Slc39a13

  • Ehlers-Danlos Syndrome-Like Spondylocheirodysplasia

  • Ehlers-Danlos Syndrome, Spondylodysplastic, Type 3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13229 SLC39A10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SLC39A10 VGNC VGNC:65354
Bos taurus SLC39A10 VGNC VGNC:34858
Macaca mulatta SLC39A10 VGNC VGNC:77540
Mus musculus SLC39A10 MGD MGI:1914515
Rattus norvegicus SLC39A10 RGD RGD:1307321
Canis familiaris SLC39A10 VGNC VGNC:57394
Others SLC39A10 NCBI