Rps6kb2 - ribosomal protein S6 kinase, polypeptide 2 Gene

Also Known as S6K2; S6K-beta-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 58988

About Rps6kb2

Chromosome 19: 4,203,990-4,213,353 reverse strand.GRCm39:CM001012.3

This gene has 12 transcripts (splice variants), 199 orthologues, 7 paralogues and is associated with 1 phenotype. Ubiquitous expression in thymus adult (RPKM 22.1), limb E14.5 (RPKM 19.7) and 28 other tissues.

Summary

Enables protein kinase activity. Acts upstream of or within protein kinase B signaling and protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in renal vasculature. Orthologous to human RPS6KB2 (ribosomal protein S6 kinase B2). [provided by Alliance of Genome Resources, Apr 2022]

Rps6kb2 Products (1)

mRNA Protein Name
NM_021485.3 NP_067460.1 ribosomal protein S6 kinase beta-2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein kinase activity IDA
IDA: Inferred from direct assay
15249583 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of insulin receptor signaling pathway IGI
IGI: Inferred from genetic interaction
15249583 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
15249583 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rps6kb2 Protein Structure

STKc_p70S6K

STKc_p70S6K: cd05584 (69 - 391)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 485 a.a.
Protein Preferred Names Protein Names

ribosomal protein S6 kinase beta-2

  • 70 kDa ribosomal protein S6 kinase 2

  • S6 kinase 2

  • p70 S6 kinase beta

  • p70 S6K-beta

  • p70 S6KB

  • p70 ribosomal S6 kinase beta

  • ribosomal protein S6 kinase, 70kD, polypeptide 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12265 RPS6KB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12266 Rps6kb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12267 Rps6kb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rps6kb2 NCBI NCBI:6199