2. Phensuximide

Phensuximide is an orally active succinimide antiepileptic and anticonvulsant agent. Phensuximide inhibits cyclic AMP and cyclic GMP accumulation in depolarized brain tissue. Phensuximide can be used for the study of seizure and petit mal.

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Phensuximide Chemical Structure

Phensuximide Chemical Structure

CAS No. : 86-34-0

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Phensuximide Related Antibodies

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1 Publications Citing Use of MCE Phensuximide

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Description

Phensuximide is an orally active succinimide antiepileptic and anticonvulsant agent. Phensuximide inhibits cyclic AMP and cyclic GMP accumulation in depolarized brain tissue. Phensuximide can be used for the study of seizure and petit mal[1][3].

IC50 & Target

IC50: cyclic AMP and cyclic GMP accumulation[2]
In Vitro

Phensuximide produce depolarization-induced accumulation of cyclic GMP or cyclic AMP levels with ID50 values of 8.00 mM or 6.20 mM in incubated slices of mouse cerebral cortex[2].
Phensuximide (0.5-2.0 mM) has the ability to competitively inhibit mephenytoin 4-hydroxylase activity in human liver microsomes, the Ki and Km values are 559 μM and 235 μM, respectively[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Phensuximide Related Antibodies
In Vivo

Phensuximide (intraperitoneal injection; 1.25 mmol/kg; single dose) induces mild changes in renal function, including: trace hematuria, increased proteinuria and decreased paminohippurate uptake in Sprague-Dawley rats[1].
Phensuximide (intraperitoneal injection; 0.3 or 0.6 mmol/kg; 5-7 days) results in transient hematuria and proteinuria, but no change in the other renal function parameters studied. It is concluded that phensuximide produces mild, transient renal effects in Fischer 344 rats, and that the Fischer 344 rat is a suitable model for studying phensuximide-induced toxicity to the urinary tract[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fischer 344 rats[1]
Dosage: 0.3 or 0.6 mmol/kg
Administration: Intraperitoneal injection; 5-7 days
Result: Induced urotoxicity following daily administration for 5-7 days in Fischer 344 rats.
Molecular Weight

189.21

Formula

C11H11NO2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C(C1=CC=CC=C1)C2)N(C)C2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (528.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2851 mL 26.4257 mL 52.8513 mL
5 mM 1.0570 mL 5.2851 mL 10.5703 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.35%

COA (252 KB) LCMS (88 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.2851 mL 26.4257 mL 52.8513 mL 132.1283 mL
5 mM 1.0570 mL 5.2851 mL 10.5703 mL 26.4257 mL
10 mM 0.5285 mL 2.6426 mL 5.2851 mL 13.2128 mL
15 mM 0.3523 mL 1.7617 mL 3.5234 mL 8.8086 mL
20 mM 0.2643 mL 1.3213 mL 2.6426 mL 6.6064 mL
25 mM 0.2114 mL 1.0570 mL 2.1141 mL 5.2851 mL
30 mM 0.1762 mL 0.8809 mL 1.7617 mL 4.4043 mL
40 mM 0.1321 mL 0.6606 mL 1.3213 mL 3.3032 mL
50 mM 0.1057 mL 0.5285 mL 1.0570 mL 2.6426 mL
60 mM 0.0881 mL 0.4404 mL 0.8809 mL 2.2021 mL
80 mM 0.0661 mL 0.3303 mL 0.6606 mL 1.6516 mL
100 mM 0.0529 mL 0.2643 mL 0.5285 mL 1.3213 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phensuximide86-34-0Inhibitorinhibitorinhibit

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