CXCL15
CXCL15, also known as Lungkine or WECHE, is a member of the ELR motif-containing CXC chemokines. CXCL15 has neutrophil chemotactic activity. CXCL15 is high expression in the lungs of mice. CXCL15 has activities associated with immunology and host defense systems[1][2].
Murine CXCL15 is first described as a protein secreted into the airway spaces, which induced neutrophil migration. Its protein structure contrasts with other CXC chemokines because it contains an extended C-terminal domain of ∼65 aa. It also has the novel function of regulating hematopoietic differentiation into erythroid cells and acting as a chemoattractant for bone marrow progenitor cells. CXCL15 is part of the ELR+ CXC chemokine family, whose members contain a non-conserved amino acid between the first two cysteines (CXC), as well as a conserved ELR motif (glutamic acid-leucinearginine) immediately preceding the CXC sequence. CXCL15 is closer to CXCL8 than other ELR+ CXCLs, indicating similar biological functions between CXCL8 and CXCL15. CXCL15 is mainly expressed in mucosae by epithelial cells. The expression can be induced in the epithelial cells by inflammatory conditions such as antigen and LPS stimulation and infection[1][2][3].
- [1]. Hal E Broxmeyer, et al. CXCL15/Lungkine has suppressive activity on proliferation and expansion of multi-potential, erythroid, granulocyte and macrophage progenitors in S-phase specific manner. Blood Cells Mol Dis. 2021 Nov;91:102594. [Content Brief]
- [2]. James J Zhu, et al. A novel bovine CXCL15 gene in the GRO chemokine gene cluster. Vet Immunol Immunopathol. 2020 Feb;220:109990. [Content Brief]
- [3]. Julia M Schmitz, et al. Expression of CXCL15 (Lungkine) in murine gastrointestinal, urogenital, and endocrine organs. J Histochem Cytochem. 2007 May;55(5):515-24. [Content Brief]
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CXCL15 Recombinant Proteins (1)
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
