2. Recombinant Proteins
  3. Immune Checkpoint Proteins
  4. Inhibitory Checkpoint Molecules
  5. LAG-3

LAG-3

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Lymphocyte activation gene-3 (LAG-3, also known as CD223), an inhibitory checkpoint, is a type I transmembrane protein expressed on activated T cells, B cells, natural killer (NK) cells, and plasmacytoid dendritic cells (pDCs). LAG-3 is a member of the immunoglobulin superfamily (IgSF). LAG-3 is a CD4 homolog that binds to MHC class II with high affinity. Ample of evidence have suggests that LAG-3 signaling play a negative regulatory role in Th1 cell activation, proliferation and cytokine secretion. Tumor cells exploit this pathway to escape from immune surveillance during tumorigenesis and cancer progression.

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