Carbohydroxamido-oxazolidines: antibacterial agents that target lipid A biosynthesis

  • Bioorg Med Chem Lett. 1999 Feb 8;9(3):313-8. doi: 10.1016/s0960-894x(98)00749-5.
M H Chen  1 ,  M G Steiner ,  S E de Laszlo ,  A A Patchett ,  M S Anderson ,  S A Hyland ,  H R Onishi ,  L L Silver ,  C R Raetz
Affiliations
  • 1. Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, New Jersey 07065, USA.
PMID: 10091675 DOI: 10.1016/s0960-894x(98)00749-5
Abstract

A series of carbohydroxamido-oxazolidine inhibitors of UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc deacetylase, the enzyme responsible for the second step in lipid A biosynthesis, was identified. The most potent analog L-161,240 showed an IC50 = 30 nM in the DEACET assay and displayed an MIC of 1-3 microg/mL against wild-type E. coli.

Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-114737
    L-573655
    UDP-3-O-[R-3-hydroxymyristoyl]-GlcNAc Deacetylase Inhibitor
    target: Bacterial
    Research Areas: Infection