Synthesis and in vitro cytotoxicity of hexacyclic camptothecin analogues

  • Bioorg Med Chem Lett. 1999 Nov 15;9(22):3203-6. doi: 10.1016/s0960-894x(99)00555-7.
S Jew  1 ,  H J Kim ,  M G Kim ,  E Y Roh ,  C I Hong ,  J K Kim ,  J H Lee ,  H Lee ,  H Park
Affiliations
  • 1. College of Pharmacy, Seoul National University, Korea.
PMID: 10576688 DOI: 10.1016/s0960-894x(99)00555-7
Abstract

A series of C(7)-N-alkylaminoethyl-C(10), C(11)-methylenedioxy- and ethylenedioxy-camptothecin (3a-g, 4a-b) were prepared. Their syntheses and in vitro cytotoxicity were reported. Among 15 derivatives, 3a and 3b showed more potent cytotoxicity than Camptothecin, especially in CAOV-3 cell line.