Solid phase synthesis of peptide aldehyde protease inhibitors. Probing the proteolytic sites of hepatitis C virus polyprotein

  • J Pept Sci. 2000 Jan;6(1):11-8. doi: 10.1002/(SICI)1099-1387(200001)6:1<11::AID-PSC229>3.0.CO;2-#.
N J Ede  1 ,  S N Eagle ,  G Wickham ,  A M Bray ,  B Warne ,  K Shoemaker ,  S Rosenberg
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PMID: 10674715 DOI: 10.1002/(SICI)1099-1387(200001)6:1<11::AID-PSC229>3.0.CO;2-#
Abstract

The solid phase synthesis of a set of peptide aldehydes derived from the NS5A/NS5B junction of hepatitis C virus (HCV) viral polyprotein is demonstrated using an oxazolidine linker and the Multipin method. Deletion of the P6 and P5 residues results in a dramatic loss of inhibitory activity.

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