Structure-activity relationship of in vitro antiviral and cytotoxic activity of semisynthetic analogues of scopadulane diterpenes

  • J Nat Prod. 2001 Oct;64(10):1318-21. doi: 10.1021/np010207l.
L Betancur-Galvis  1 ,  C Zuluaga ,  M Arnó ,  M A González ,  R J Zaragozá
Affiliations
  • 1. Grupo Inmunovirología-Biogénesis, Universidad de Antioquia, A.A1226, Medellín-Colombia, Spain. [email protected]
PMID: 11678658 DOI: 10.1021/np010207l
Abstract

Fourteen semisynthetic compounds derived from the natural scopadulane-type diterpenes thyrsiflorin A (4), B (5), and C (6), including several precursors, have been examined in vitro for their antiherpetic activity against Herpes simplex virus type II (HSV-2) and cytotoxicity against two human tumor cell lines. Four of these compounds showed moderate antiherpetic activity, but none of them exhibited a significant cytotoxicity against the cell lines used. Some structure-activity relationships have been identified for the Antiviral activity in these scopadulane derivatives as well as important structural features for the cytotoxic activity.