Gas-chromatographic determination of camylofine dihydrochloride in tablets and suppositories

  • J Chromatogr. 1976 Feb 4;117(1):161-6. doi: 10.1016/s0021-9673(00)81077-8.
E Crombez ,  W van den Bossche ,  P De Moerloose
PMID: 1249147 DOI: 10.1016/s0021-9673(00)81077-8
Abstract

A gas-chromatographic method for the quantitative determination of camylofine dihydrochloride, a spasmolytic agent, is described. The analysis is made on a porous polymer packing material, by determining the 3-methyl-1-butanol formed on alkaline hydrolysis of the drug. The method has been applied to the quantitative determination of the drug in two galenical forms, namely tablets and suppositories, in the presence of papaverine hydrochloride, codeine phosphate, novalgin and aminopyrine.

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