Camylofin dihydrochloride
Camylofine dihydrochloride is an antispasmodic agent with myogenic and neurogenic effects. Camylofine dihydrochloride exhibits mild anticholinergic activity and blocks the M3 receptors on colonic smooth muscle. Camylofine dihydrochloride inhibits phosphodiesterase, elevates intracellular cAMP levels and reduces intracellular Ca2+ levels, thereby promoting smooth muscle relaxation. Camylofine dihydrochloride can be used in studies related to antispasmodia, gastrointestinal smooth muscle and ulcerative colitis.
For research use only. We do not sell to patients.
- CAS No.: 5892-41-1
- Formula: C19H34Cl2N2O2
- Molecular Weight:393.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
M3 receptors |
In Vitro
The cumulative release rate of Camylofine dihydrochloride from Camylofine dihydrochloride-loaded Eudragit® S-100-coated chitosan microspheres reaches 72.5% in the presence of 3% w/v rat caecal content within 24 h, while it is 59.2% in the absence of rat caecal content[1].
After incubation for 24 h in a release system containing 3% w/v cecal contents from enzyme-induced rats treated for 5 days, the cumulative release rate of Camylofine dihydrochloride from Camylofine dihydrochloride-loaded Eudragit® S-100-coated chitosan microspheres reaches 95.5%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Aqueous solution of Camylofine dihydrochloride (0.71 mg/kg; oral administration) reduces the Ca2+ concentration in colonic smooth muscle tissue to 1.989 mg/g colon in TNBS-induced colitis rats, whereas the concentration is 3.807 mg/g colon in the colitis control group[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Albino rats (either sex, 10-12 weeks old, 100-150 g, TNBS-induced ulcerative colitis)[1]
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Dosage:0.71 mg/kg
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Administration:p.o. (Camylofine dihydrochloride aqueous solution); repeated dosing; 11 days
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Result:Resulted in a colonic smooth-muscle Ca²⁺ concentration of 1.989 mg/g colon versus 3.807 mg/g colon in the colitis control group.
Chemical Information
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CAS No. 5892-41-1
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Molecular Weight 393.39
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Formula C19H34Cl2N2O2
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SMILES
O=C(C(C1=CC=CC=C1)NCCN(CC)CC)OCCC(C)C.[H]Cl.[H]Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Camylofin dihydrochloride Related Classifications
HY-B1230A Related Classifications
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