Antibiotics from basidiomycetes. XLI. Clavicoronic acid, a novel inhibitor of reverse transcriptases from Clavicorona pyxidata (Pers. ex Fr.) Doty

  • J Antibiot (Tokyo). 1992 Jan;45(1):29-37. doi: 10.7164/antibiotics.45.29.
G Erkel  1 ,  T Anke ,  A Gimenez ,  W Steglich
Affiliations
  • 1. LB Biotechnologie der Universität, Kaiserslautern, Germany.
PMID: 1372310 DOI: 10.7164/antibiotics.45.29
Abstract

A novel inhibitor of RNA-directed DNA-polymerases was isolated from fermentations of Clavicorona pyxidata. Its structure was elucidated by spectroscopic methods. Clavicoronic acid (1) is a noncompetitive inhibitor of avian myeloblastosis virus (Ki 130 microM) and Moloney murine leukemia virus (Ki 68 microM) reverse transcriptases. In permeabilized cells and isolated nucleic DNA- and RNA-synthesis are not affected. Clavicoronic acid markedly inhibits the multiplication of vesicular stomatitis virus in baby hamster kidney cells by interfering with this virus's RNA-directed RNA-polymerase. 1 exhibits no cytotoxic and very weak antimicrobial activities.

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