A novel series of histone deacetylase inhibitors incorporating hetero aromatic ring systems as connection units

  • Bioorg Med Chem Lett. 2003 Nov 3;13(21):3817-20. doi: 10.1016/j.bmcl.2003.07.012.
Yujia Dai  1 ,  Yan Guo ,  Michael L Curtin ,  Junling Li ,  Lori J Pease ,  Jun Guo ,  Patrick A Marcotte ,  Keith B Glaser ,  Steven K Davidsen ,  Michael R Michaelides
Affiliations
  • 1. Cancer Research, Abbott Laboratories, Department R47J, Building AP10, 100 Abbott Park Road, Abbott Park, IL 60031, USA. [email protected]
PMID: 14552787 DOI: 10.1016/j.bmcl.2003.07.012
Abstract

A series of structurally novel HDAC inhibitors, in which a hetero aromatic ring connects the spacer with the hydrophobic group, has been designed and synthesized. These new inhibitors are very potent in in vitro enzymatic assays and display antiproliferation activity against two human Cancer cell lines.