Design, synthesis, and antiproliferative activity of some novel aminosubstituted xanthenones, able to overcome multidrug resistance toward MES-SA/Dx5 cells

  • Bioorg Med Chem Lett. 2005 Nov 15;15(22):5057-60. doi: 10.1016/j.bmcl.2005.07.079.
Ioannis K Kostakis  1 ,  Roxane Tenta ,  Nicole Pouli ,  Panagiotis Marakos ,  Alexios-Leandros Skaltsounis ,  Harris Pratsinis ,  Dimitris Kletsas
Affiliations
  • 1. Division of Pharmaceutical Chemistry, Department of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens 15771, Greece.
PMID: 16169719 DOI: 10.1016/j.bmcl.2005.07.079
Abstract

A series of novel xanthenone aminoderivatives and their pyrazole-fused counterparts possessing structural analogy to the potent Anticancer agent 9-methoxypyrazoloacridine (PZA) reported. These compounds exhibited an interesting cytotoxic activity against a panel of cell lines. Most noticeably, they retain activity against the multidrug resistant MES-SA/Dx5 subline, showing resistant factors close to 1.