Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl purine nucleosides as inhibitors of hepatitis C virus RNA replication

  • Bioorg Med Chem Lett. 2006 Mar 15;16(6):1712-5. doi: 10.1016/j.bmcl.2005.12.002.
Jeremy L Clark  1 ,  J Christian Mason ,  Laurent Hollecker ,  Lieven J Stuyver ,  Phillip M Tharnish ,  Tamara R McBrayer ,  Michael J Otto ,  Phillip A Furman ,  Raymond F Schinazi ,  Kyoichi A Watanabe
Affiliations
PMID: 16368235 DOI: 10.1016/j.bmcl.2005.12.002
Abstract

A series of purine nucleosides containing the 2'-deoxy-2'-fluoro-2'-C-methylribofuranosyl moiety were synthesized and evaluated as potential inhibitors of the hepatitis C virus in vitro. Of the nucleosides that were synthesized, only those possessing a 2-amino group on the purine base reduced the levels of HCV RNA in a subgenomic replicon assay.