Guaiane sesquiterpenoids from Torilis japonica and their cytotoxic effects on human cancer cell lines

  • Arch Pharm Res. 2006 Feb;29(2):131-4. doi: 10.1007/BF02974273.
Hye Won Park  1 ,  Sang-Un Choi ,  Nam-In Baek ,  Sung-Hoon Kim ,  Jae Soon Eun ,  Jae Heon Yang ,  Dae Keun Kim
Affiliations
  • 1. College of Pharmacy, Woosuk University, Samrye 565-701, Korea.
PMID: 16526276 DOI: 10.1007/BF02974273
Abstract

A new compound 2 and two known guaiane-type sesquiterpenoids were isolated from the methylene chloride-soluble fraction of the methanolic extract of the fruits of Torilis japonica (Umbelliferae) through repeated silica gel and Sephadex LH-20 column chromatography. Their chemical structures were elucidated as torilin (1), 11-acetoxy-8-angeloyloxy-1beta-hydroxy-4-guaien-3-one (1beta-hydroxytorilin, 2), and 11-acetoxy-8-angeloyloxy-1alpha-hydroxy-4-guaien-3-one (1alpha-hydroxytorilin, 3) by spectroscopic analysis. Compounds 1-3 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells.

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