Antiviral activities against herpes simplex virus type 1 by HPH derivatives and their structure-activity relationships

  • Bioorg Med Chem Lett. 2008 Jan 1;18(1):371-4. doi: 10.1016/j.bmcl.2007.10.065.
Tetsuji Hosono  1 ,  Kazumi Yokomizo ,  Akiyuki Hamasaki ,  Yoshinari Okamoto ,  Tadashi Okawara ,  Masami Otsuka ,  Ryozaburo Mukai ,  Keitarou Suzuki
Affiliations
  • 1. Laboratory of Medicinal Microbiology, Yokohama College of Pharmacy, Kanagawa 245-0066, Japan. [email protected]
PMID: 17981031 DOI: 10.1016/j.bmcl.2007.10.065
Abstract

The compound named Histidine-pyridine-histidine (HPH) is an oxygen-activating ligand derived from the structure of bleomycin. We synthesized HPH derivatives, namely HPH-1 to -8, and investigated their Antiviral activities against herpes simplex virus type 1. HPH-8 showed potent Antiviral activity with an EC50 of 15 microM, and relatively high cytotoxicity with a CC50 of 37 microM. In contrast, HPH-4 indicated a weaker Antiviral activity with an EC50 of 79 microM, but exhibited a far more less cytotoxicity (CC50 500 microM). Other HPH derivatives showed no effects against Antiviral activities and cytotoxicities.