Synthesis and bioevaluation of 22-hydroxyacuminatine analogs

  • Bioorg Med Chem Lett. 2008 Mar 15;18(6):2143-6. doi: 10.1016/j.bmcl.2008.01.082.
François Grillet  1 ,  Barbora Baumlová ,  Grégoire Prévost ,  Jean-François Constant ,  Sophie Chaumeron ,  Dennis C H Bigg ,  Andrew E Greene ,  Alice Kanazawa
Affiliations
  • 1. Département de Chimie Moléculaire, UMR-5250, ICMG FR-2607, CNRS-Université Joseph Fourier, BP-53, 38041 Grenoble, France.
PMID: 18276141 DOI: 10.1016/j.bmcl.2008.01.082
Abstract

A series of 22-hydroxyacuminatine analogs was prepared by using different Friedländer condensations. Several of the new compounds were tested for antiproliferative activity on Cancer cell lines and for Topoisomerase I inhibitory activity.