Myeloperoxidase inhibitory and radical scavenging activities of flavones from Pterogyne nitens

  • Chem Pharm Bull (Tokyo). 2008 May;56(5):723-6. doi: 10.1248/cpb.56.723.
Daniara Cristina Fernandes  1 ,  Luis Octávio Regasini ,  José Carlos Rebuglio Vellosa ,  Patrícia Mendonça Pauletti ,  Ian Castro-Gamboa ,  Vanderlan Silva Bolzani ,  Olga Maria Mascarenhas Oliveira ,  Dulce Helena Siqueira Silva
Affiliations
  • 1. NuBBE-Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais, Department of Organic Chemistry, Institute of Chemistry, UNESP-São Paulo State University, Brazil.
PMID: 18451567 DOI: 10.1248/cpb.56.723
Abstract

Two new flavone glucosides, nitensosides A and B (1, 2), together with four known compounds, sorbifolin (3), sorbifolin 6-O-beta-glucopyranoside (4), pedalitin (5), and pedalitin 6-O-beta-glucopyranoside (6) were isolated from Pterogyne nitens. Their structures were elucidated from 1D and 2D NMR analysis, as well as by high resolution mass spectrometry. All the isolated Flavones were evaluated for their myeloperoxidase (MPO) inhibitory activity. The most active compound, pedalitin, exhibited IC50 value of 3.75 nM on MPO. Additionally, the radical-scavenging capacity of Flavones 1-6 was evaluated towards ABTS and DPPH radicals and compared to standard compounds quercetin and Trolox.

Products