Alkaloids from Pachysandra terminalis inhibit breast cancer invasion and have potential for development as antimetastasis therapeutic agents

  • J Nat Prod. 2012 Jul 27;75(7):1305-11. doi: 10.1021/np300207c.
Hui-Yuan Zhai  1 ,  Chuan Zhao ,  Ning Zhang ,  Mei-Na Jin ,  Sheng-An Tang ,  Nan Qin ,  De-Xin Kong ,  Hong-Quan Duan
Affiliations
  • 1. Tianjin Key Laboratory on Technologies Enabling Development Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University , Tianjin 300070, People's Republic of China.
PMID: 22804108 DOI: 10.1021/np300207c
Abstract

The aim of the present study was to identify potentially useful natural compounds for the development of novel therapeutic agents to inhibit metastasis. A phytochemical investigation of Pachysandra terminalis resulted in the isolation of seven new pregnane Alkaloids, terminamines A-G (1-7), and seven known Alkaloids (8-14). The structures of 1-7 were elucidated by 1D- and 2D-NMR spectroscopic and mass spectrometric methods. Compounds 1-5 and 8-14 inhibited the migration of MB-MDA-231 breast Cancer cells induced by the chemokine epithelial growth factor. In addition, compound 1 inhibited phosphorylation of Integrin β(1), which plays an important role in MB-MDA-231 cell adhesion and metastasis.