Neolignans and phenylpropanoids from the roots of Piper taiwanense and their antiplatelet and antitubercular activities

  • Phytochemistry. 2013 Sep:93:203-9. doi: 10.1016/j.phytochem.2013.03.008.
Si Chen  1 ,  Hung-Yi Huang ,  Ming-Jen Cheng ,  Chin-Chung Wu ,  Tsutomu Ishikawa ,  Chien-Fang Peng ,  Hsun-Shou Chang ,  Chyi-Jia Wang ,  Su-Ling Wong ,  Ih-Sheng Chen
Affiliations
  • 1. Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC.
PMID: 23582215 DOI: 10.1016/j.phytochem.2013.03.008
Abstract

Bioassay-guided fractionation of roots from Piper taiwanense led to isolation of three neolignans, diallylcatechol (1) and neotaiwanensols A, B (2, 3), two diphenylpropanoid ethers, taiwandimerols A, B (4, 5), with one phenylpropanoid, 2,3-diacetoxy-1-methoxy-5-allylbenzene (6), previously unknown in nature, together with 18 known compounds (7-24). Their structures were elucidated by spectroscopic evidence. Among the isolates, hydroxychavicol acetate (7), and 4-allylcatechol (8) showed potent inhibitory activities against platelet aggregation induced by Collagen, with IC50 values of 2.1, and 5.3 μM, respectively. Hydroxychavicol acetate (7), 4-allylcatechol (8), and trans-caffeicaldehyde (9) showed antitubercular activities against Mycobacterium tuberculosis H37Rv, with MIC values of 30.3, 27.6, and 25.5 μg/mL, respectively.

Keywords
Antiplatelet activity; Antitubercular activity; Neolignan; Phenylpropanoid; Piper taiwanense; Piperaceae; Root.
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