Synthesis and anti-cancer cell activity of pseudo-ginsenoside Rh2

  • Steroids. 2014 Dec;92:1-6. doi: 10.1016/j.steroids.2014.08.021.
Guangtao Qian  1 ,  Zhicai Wang  1 ,  Jinyu Zhao  1 ,  Dandan Li  1 ,  Wei Gao  1 ,  Baohui Wang  1 ,  Dayuan Sui  2 ,  Xiangru Qu  2 ,  Yanping Chen  3
Affiliations
  • 1. Department of Chemistry, Jilin University, Changchun, Jilin 130021, China.
  • 2. Department of Pharmaceutical Sciences, Jilin University, Changchun, Jilin 130021, China.
  • 3. Department of Chemistry, Jilin University, Changchun, Jilin 130021, China. Electronic address: [email protected].
PMID: 25218677 DOI: 10.1016/j.steroids.2014.08.021
Abstract

β-d-Glucopyranoside,(3β,12β,20E)-12,25-dihydroxydammar-20(22)-en-3-yl (pseudo-ginsenoside Rh2) and its 20Z-isomer were synthesized from ginsenoside Rh2 under a mild condition, via a simple three-step called acetylation, elimination-addition and saponification. In addition, their activities were evaluated by eight different human tumor cells, compared with ginsenoside Rh2 group. Results indicated that the reaction in the side chain might greatly enhance the anti-proliferative activity of ginsenosides.

Keywords
Ginsenoside; Human tumor cells; Steroid derivatives; Synthesis.
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