Design, synthesis and structure--activity relationship (SAR) studies of imidazo[4,5-b]pyridine derived purine isosteres and their potential as cytotoxic agents

  • Eur J Med Chem. 2015 Jan 7:89:21-31. doi: 10.1016/j.ejmech.2014.10.037.
Ayyiliath M Sajith  1 ,  K K Abdul Khader  2 ,  Nithin Joshi  3 ,  Manchala Nageswar Reddy  4 ,  M Syed Ali Padusha  2 ,  H P Nagaswarupa  5 ,  M Nibin Joy  6 ,  Yadav D Bodke  6 ,  Ranjith P Karuvalam  7 ,  Rinti Banerjee  3 ,  A Muralidharan  8 ,  P Rajendra  4
Affiliations
  • 1. Department of Chemistry, Nehru Arts and Science College, Kannur University, Kannur, India; Post Graduate and Research Department of Chemistry, Kasargod Govt. College, Kannur University, Kasaragod, India. Electronic address: [email protected].
  • 2. Post Graduate and Research Department of Chemistry, Jamal Mohamed College, Bharathidasan University, Tiruchirapalli, India.
  • 3. Department of Biosciences and Bioengineering, IIT Mumbai, India.
  • 4. Central University of Kerala, Vidyanagar, Kasaragod, Periya, Kerala, India.
  • 5. Research Center, Department of Chemistry, East West Institute of Technology, Bangalore, India.
  • 6. Department of P.G. Studies and Research in Industrial Chemistry, Kuvempu University, Jnana Sahyadri, Shankaraghatta, Shimoga, Karnataka, India.
  • 7. School of Chemical Sciences, Kannur University, Payyanur Campus, Edat P.O. Kannur, Kerala, India.
  • 8. Department of Chemistry, Nehru Arts and Science College, Kannur University, Kannur, India; Post Graduate and Research Department of Chemistry, Kasargod Govt. College, Kannur University, Kasaragod, India.
PMID: 25462222 DOI: 10.1016/j.ejmech.2014.10.037
Abstract

Drug resistance to chemotherapeutic agents paved the way to develop novel synthetic molecules which are active on MDR Cancer cell lines. Regio-isomeric imidazo[4,5-b]pyridine analogues were synthesized and evaluated for their cytotoxic activity against a range of Cancer cell lines. The structure-activity relationship (SAR) studies of the imidazopyridine analogues are also described. Analogue 6b displayed strong cytotoxicity and good microsomal stability.

Keywords
Chemotherapy; Cytotoxic studies; Imidazo[4,5-b]pyridine analogues; Suzuki coupling.