Iminolactones from Schizophyllum commune

  • J Nat Prod. 2015 May 22;78(5):1165-8. doi: 10.1021/np500836y.
Xuemei Liu  1  2 ,  Karla Frydenvang  1 ,  Huizhen Liu  1 ,  Lin Zhai  3 ,  Ming Chen  3 ,  Carl Erik Olsen  4 ,  Søren Brøgger Christensen  1
Affiliations
  • 1. †Department of Drug Design and Pharmacology, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen Ø, Denmark.
  • 2. ‡Chemistry Department, Guangxi Medical University, Shuang Yong Road, Nan Ning, Guang Xi, People's Republic of China.
  • 3. §Department of Clinical Microbiology 7602, Rigshospitalet, Tagensvej 20, DK-2200 Copenhagen N, Denmark.
  • 4. ⊥Department of Basic Sciences and Environment, University of Copenhagen, Thorvaldsensvej 40, DK-1871 Frederiksberg C, Denmark.
PMID: 25951057 DOI: 10.1021/np500836y
Abstract

Schizines A (1) and B (2), the first naturally occurring iminolactones (3,6-dihydro-2H-1,4-oxazin-2-one derivatives) to be reported, have been isolated from the fruiting bodies of Schizophyllym commune. In principle the 2-oxazinone moiety might have been formed by a reaction between the amino acid phenylalanine or tryptophan and an 2α-hydroxy-1-ketomarasmone. The Alkaloids are unusual in that the carboxyl group of the amino acid precursor is preserved during the biosynthesis. The compounds showed some inhibition of the growth of Cancer cells.