Cytotoxic triterpene saponins from Cercodemas anceps

  • Bioorg Med Chem Lett. 2015 Aug 15;25(16):3151-6. doi: 10.1016/j.bmcl.2015.06.005.
Nguyen Xuan Cuong  1 ,  Le Thi Vien  1 ,  Tran Thi Hong Hanh  1 ,  Nguyen Phuong Thao  1 ,  Do Thi Thao  2 ,  Nguyen Van Thanh  1 ,  Nguyen Hoai Nam  1 ,  Do Cong Thung  3 ,  Phan Van Kiem  1 ,  Chau Van Minh  4
Affiliations
  • 1. Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
  • 2. Institute of Biotechnology (IBT), VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
  • 3. Institute of Marine Environment and Resources (IMER), VAST, 246 Da Nang, Haiphong, Viet Nam.
  • 4. Institute of Marine Biochemistry (IMBC), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam. Electronic address: [email protected].
PMID: 26099533 DOI: 10.1016/j.bmcl.2015.06.005
Abstract

Seven holostane-type triterpene saponins (1-7), including five new compounds namely cercodemasoides A-E (2-6), were isolated from the sea cucumber Cercodemas anceps. Their structures were elucidated on the basis of spectroscopic evidence including HR ESI MS, ESI MS/MS, 1D and 2D NMR. The cytotoxic effects of isolated compounds were evaluated by SRB method on five human Cancer cell lines including Hep-G2 (hepatoma Cancer), KB (epidermoid carcinoma), LNCaP (prostate Cancer), MCF7 (breast Cancer), and SK-Mel2 (melanoma). Compounds 1-7 showed potent cytotoxicity on five tested Cancer cell lines with IC50 values ranging from 0.03 ± 0.01 to 7.36 ± 0.46 μM. With respect to the potent cytotoxicity of the isolated saponins, further studies are required to confirm efficacy in vivo and the mechanism of cytotoxic effects.

Keywords
Cercodemas anceps; Cercodemasoide; Cucumariidae; Cytotoxic activity; Sea cucumber.