Four New Cyclohexylideneacetonitrile Derivatives from the Hypocotyl of Mangrove (Bruguiera gymnorrhiza)

  • Molecules. 2015 Aug 12;20(8):14565-75. doi: 10.3390/molecules200814565.
Xiang-Xi Yi  1 ,  Jia-Gang Deng  2 ,  Cheng-Hai Gao  3 ,  Xiao-Tao Hou  4 ,  Fei Li  5 ,  Zhi-Ping Wang  6 ,  Er-Wei Hao  7 ,  Yan Xie  8 ,  Zheng-Cai Du  9 ,  Hui-Xue Huang  10 ,  Ri-Ming Huang  11  12
Affiliations
  • 1. School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China. [email protected].
  • 2. School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China. [email protected].
  • 3. Guangxi Key Laboratory of Marine Environmental Science, Guangxi Academy of Sciences, Nanning 530007, China. [email protected].
  • 4. School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China. [email protected].
  • 5. Guangxi Key Laboratory of Marine Environmental Science, Guangxi Academy of Sciences, Nanning 530007, China. [email protected].
  • 6. School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China. [email protected].
  • 7. School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China. [email protected].
  • 8. School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China. [email protected].
  • 9. School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China. [email protected].
  • 10. School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China. [email protected].
  • 11. Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China. [email protected].
  • 12. Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China. [email protected].
PMID: 26274945 DOI: 10.3390/molecules200814565
Abstract

Four new cyclohexylideneacetonitrile derivatives 1-4, named menisdaurins B-E, as well as three known cyclohexylideneacetonitrile derivatives--menisdaurin (5), coclauril (6), and menisdaurilide (7)--were isolated from the hypocotyl of a mangrove (Bruguiera gymnorrhiza). The structures of the isolates were elucidated on the basis of extensive spectroscopic analysis. Compounds 1-7 showed anti-Hepatitis B virus (HBV) activities, with EC50 values ranging from 5.1 ± 0.2 μg/mL to 87.7 ± 5.8 μg/mL.

Keywords
Bruguiera gymnorrhiza; antiviral; cyclohexylideneacetonitrile derivative.
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