An alternative route to the arylvinyltriazole nucleosides

  • Bioorg Med Chem Lett. 2016 Jul 15;26(14):3223-3225. doi: 10.1016/j.bmcl.2016.05.072.
Mikhail V Chudinov  1 ,  Alexander N Prutkov  2 ,  Andrey V Matveev  2 ,  Lyubov E Grebenkina  2 ,  Irina D Konstantinova  3 ,  Yulia V Berezovskaya  4
Affiliations
  • 1. Lomonosov Institute of Fine Chemical Tehnologies, Moscow Technological University, Vernadskogo Pr. 78, 119454, Russia. Electronic address: [email protected].
  • 2. Lomonosov Institute of Fine Chemical Tehnologies, Moscow Technological University, Vernadskogo Pr. 78, 119454, Russia.
  • 3. Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya St. 16/10, 117997 GSP, Moscow B-437, Russia.
  • 4. Moscow Institute of Physics and Technology (State University), 9 Institutskiy per., Dolgoprudny, Moscow Region 141700, Russia.
PMID: 27262598 DOI: 10.1016/j.bmcl.2016.05.072
Abstract

A new pathway to synthesis of arylvinyl ribavirin analogues is developed which makes it possible to obtain not only trans- but also cis-isomers at vinyl bond. By this route eight ribavirin 5-arylvinyl analogues are synthesized and their Antiviral activity is evaluated.

Keywords
HCV; Nucleoside analogues; Triazole nucleosides.