Selective IKur Inhibitors for the Potential Treatment of Atrial Fibrillation: Optimization of the Phenyl Quinazoline Series Leading to Clinical Candidate 5-[5-Phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide

  • J Med Chem. 2017 May 11;60(9):3795-3803. doi: 10.1021/acs.jmedchem.6b01889.
Prashantha Gunaga  1  2 ,  John Lloyd  1  2 ,  Somanadham Mummadi  1  2 ,  Abhisek Banerjee  1  2 ,  Naveen Kumar Dhondi  1  2 ,  James Hennan  1  2 ,  Veena Subray  1  2 ,  Ramya Jayaram  1  2 ,  Nagendra Rajugowda  1  2 ,  Kommuri Umamaheshwar Reddy  1  2 ,  Duraimurugan Kumaraguru  1  2 ,  Umasankar Mandal  1  2 ,  Dasthagiri Beldona  1  2 ,  Ashok Kumar Adisechen  1  2 ,  Navnath Yadav  1  2 ,  Jayakumar Warrier  1  2 ,  James A Johnson  1  2 ,  Harinath Sale  1  2 ,  Siva Prasad Putlur  1  2 ,  Ajay Saxena  1  2 ,  Anjaneya Chimalakonda  1  2 ,  Sandhya Mandlekar  1  2 ,  MaryLee Conder  1  2 ,  Dezhi Xing  1  2 ,  Arun Kumar Gupta  1  2 ,  Anuradha Gupta  1  2 ,  Richard Rampulla  1  2 ,  Arvind Mathur  1  2 ,  Paul Levesque  1  2 ,  Ruth R Wexler  1  2 ,  Heather J Finlay  1  2
Affiliations
  • 1. Department of Discovery Chemistry, ‡Department of Biology, and §Department of Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Research and Development , P.O. Box 5400, Princeton, New Jersey 08543-5400, United States.
  • 2. Department of Discovery Chemistry, Department of Biology, @Department of Biopharmaceutics, #Department of Pharmaceutical Candidate Optimization, and ∇Biocon BMS R&D Center, Syngene International Limited, BMS India Pvt. Limited , Biocon Park, Jigani Link Road, Bommasandra IV, Bangalore 560099, India.
Abstract

We have recently disclosed 5-phenyl-N-(pyridin-2-ylmethyl)-2-(pyrimidin-5-yl)quinazolin-4-amine 1 as a potent IKur current blocker with selectivity versus hERG, Na and CA channels, and an acceptable preclinical PK profile. Upon further characterization in vivo, compound 1 demonstrated an unacceptable level of brain penetration. In an effort to reduce the level of brain penetration while maintaining the overall profile, SAR was developed at the C2' position for a series of close analogues by employing hydrogen bond donors. As a result, 5-[5-phenyl-4-(pyridin-2-ylmethylamino)quinazolin-2-yl]pyridine-3-sulfonamide (25) was identified as the lead compound in this series. Compound 25 showed robust effects in rabbit and canine pharmacodynamic models and an acceptable cross-species pharmacokinetic profile and was advanced as the clinical candidate. Further optimization of 25 to mitigate pH-dependent absorption resulted in identification of the corresponding phosphoramide prodrug (29) with an improved solubility and pharmacokinetic profile.

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