Four New Lignans from Kadsura Interior and Their Bioactivity

  • Molecules. 2018 May 26;23(6):1279. doi: 10.3390/molecules23061279.
Jiu-Shi Liu  1 ,  Jin Zhang  2  3 ,  Yao-Dong Qi  4 ,  Xiao-Guang Jia  5 ,  Ben-Gang Zhang  6 ,  Hai-Tao Liu  7
Affiliations
  • 1. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China. [email protected].
  • 2. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China. [email protected].
  • 3. Institute of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830011, China. [email protected].
  • 4. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China. [email protected].
  • 5. Institute of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi 830011, China. [email protected].
  • 6. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China. [email protected].
  • 7. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China. [email protected].
PMID: 29861462 DOI: 10.3390/molecules23061279
Abstract

A phytochemical investigation of the stems of Kadsura interior has led to an isolation of four new Lignans, named kadsutherin E⁻H (1⁻4), together with two known Lignans (5⁻6). The structures of the four new compounds were established on the basis of comprehensive spectroscopic analyses. Compounds 1⁻6 exhibited inhibition against adenosine diphosphate (ADP) induced platelet aggregation. Among the isolated compounds, kadsutherin F (2) showed the strongest anti-platelet aggregation activity with an inhibition of 49.47%.

Keywords
Kadsura interior; anti-platelet aggregation; kadsutherin E-H; lignan.
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