Dual effects of propyl gallate and its methylglyoxal adduct on carbonyl stress and oxidative stress

  • Food Chem. 2018 Nov 1;265:227-232. doi: 10.1016/j.foodchem.2018.04.045.
Hengqing Cui  1 Fei Tao  2 Yu Hou  1 Yongling Lu  1 Tiesong Zheng  1 Shengmin Sang  3 Lishuang Lv  4
Affiliations
  • 1. Department of Food Science and Technology, Nanjing Normal University, 122# Ninghai Road, Nanjing 210097, PR China.
  • 2. College of Standardization, China Jiliang University, 258# Xueyuan Street, Hangzhou 310018, PR China.
  • 3. Laboratory for Functional Foods and Human Health, Center for Excellence in Post-Harvest Technologies, North Carolina Agricultural and Technical State University, North Carolina Research Campus, 500 Laureate Way, Kannapolis, NC 28081, United States. Electronic address: [email protected].
  • 4. Department of Food Science and Technology, Nanjing Normal University, 122# Ninghai Road, Nanjing 210097, PR China. Electronic address: [email protected].
Abstract

In the present study, we investigated the trapping of methylglyoxal (MGO) by propyl gallate (PG), a known food grade antioxidant, and the anti-carbonyl and anti-oxidative properties of the mono-MGO adduct of PG (MM-PG). Our result indicated that more than 77.5% MGO was suppressed by PG after a 30 min incubation of PG with MGO, which was much more effective than gallic acid (15.2%). For the first time, MM-PG was purified, and its structure was elucidated based on the analysis of its 1H, 13C, and 2D-NMR data. We also demonstrated that MM-PG had strong anti-oxidative and anti-carbonyl activities. Furthermore, PG could trap the MGO generated during the preparation of roasted pork, and both mono- and di- MGO adducts of PG were detected in the roasted pork system using LC/MS technique. Thus, PG could be widely applied in the food system for inhibiting the formation of both carbonyl species and oxidative species.

Keywords
Carbonyl stress; Food processing; Methylglyoxal; Oxidative stress; Propyl gallate (PubChem CID: 4947).