Synthesis, antioxidant and antitumoral activities of 5'-arylchalcogeno-3-aminothymidine (ACAT) derivatives

  • Medchemcomm. 2016 Dec 22;8(2):408-414. doi: 10.1039/c6md00640j.
Raquel Mello da Rosa  1 ,  Bruna Candia Piccoli  2 ,  Fernanda D'Avila da Silva  2 ,  Luciano Dornelles  1 ,  João B T Rocha  2 ,  Mariana Souza Sonego  3 ,  Karine Rech Begnini  3 ,  Tiago Collares  3 ,  Fabiana K Seixas  3 ,  Oscar E D Rodrigues  1
Affiliations
  • 1. LabSelen-NanoBio - Departamento de Química , Universidade Federal de Santa Maria , Santa Maria , Brazil . Email: [email protected].
  • 2. Programa de Pós-graduação em Ciências Biológicas: Bioquímica Toxicológica , Universidade Federal de Santa Maria , Santa Maria , Brazil.
  • 3. Molecular and Cellular Oncology Group , Graduate Program in Biotechnology , Universidade Federal de Pelotas , Pelotas , Brazil.
PMID: 30108758 DOI: 10.1039/c6md00640j
Abstract

This article presents the preparation and in vitro biological activities of new 5'-arylchalcogeno-3-aminothymidine derivatives as Antioxidants (inhibition of lipid peroxidation, scavenging of the free radical 2,2-diphenylpicrylhydrazyl and demonstration of a thiol peroxidase-like activity) as well as antitumoral agents against bladder carcinoma 5637. The chalcogeno-aminothymidines presented prominent activity in the tests for both biological properties, showing a direct relation with the chalcogenium atom.