New triterpenoids and PTP1B inhibitory constituents of Pseudolarix amabilis

  • Fitoterapia. 2019 Nov;139:104414. doi: 10.1016/j.fitote.2019.104414.
Chun Lei  1 ,  Qing-Hua Huang  1 ,  Ting Zhao  1 ,  Pei-Pei Wang  2 ,  Jing-Ya Li  2 ,  Jia Li  2 ,  Ai-Jun Hou  3
Affiliations
  • 1. School of Pharmacy, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 201203, PR China.
  • 2. National Center for Drug Screening, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China.
  • 3. School of Pharmacy, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 201203, PR China. Electronic address: [email protected].
PMID: 31705950 DOI: 10.1016/j.fitote.2019.104414
Abstract

Six new triterpenoids, pseudolarins A-F (1-6), were isolated from the twigs of Pseudolarix amabilis, together with four known triterpenoids (7-10) and five known Diterpenoids (11-15). Their structures were determined by extensive spectroscopic analysis, and the absolute configuration of 1 was assigned by single-crystal X-ray diffraction. Compound 1 is a 3,4:9,10-diseco-cycloartane triterpenoid possessing an unprecedented 5/5/7/6/5/6/5 ring system. Compounds 1, 5, 7, 9-11, and 13 showed inhibition against protein tyrosine Phosphatase 1B (PTP1B) in vitro.

Keywords
Protein tyrosine phosphatase 1B; Pseudolarins A–F; Pseudolarix amabilis; Triterpenoids.
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