Clerodane diterpenoids with potential anti-inflammatory activity from the leaves and twigs of Callicarpa cathayana

  • Chin J Nat Med. 2019 Dec;17(12):953-962. doi: 10.1016/S1875-5364(19)30118-9.
Yuan Wang  1 ,  Jing Lin  1 ,  Qi Wang  1 ,  Kun Shang  1 ,  De-Bing Pu  1 ,  Rui-Han Zhang  1 ,  Xiao-Li Li  1 ,  Xiao-Chang Dai  1 ,  Xing-Jie Zhang  2 ,  Wei-Lie Xiao  3
Affiliations
  • 1. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China.
  • 2. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China. Electronic address: [email protected].
  • 3. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology, Yunnan University, Kunming 650091, China. Electronic address: [email protected].
PMID: 31882051 DOI: 10.1016/S1875-5364(19)30118-9
Abstract

Phytochemical investigation of the leaves and twigs of Callicarpa cathayana led to the isolation of six new clerodane Diterpenoids, cathayanalactones A-F (1-6), together with seven analogues (7-13). Their structures were established by extensive NMR analyses together with experimental and calculated ECD spectra analyses. Compounds 1, 2, 3, 7 and 11 showed inhibitory activities on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells.

Keywords
Anti-inflammatory activity; Callicarpa cathayana; Clerodane diterpenoids; Nitric oxide.
Products