Schomburgkixanthone, a novel bixanthone from the twigs of Garcinia schomburgkiana

  • Nat Prod Res. 2021 Nov;35(21):3613-3618. doi: 10.1080/14786419.2020.1716351.
Thi My Lien Do  1 ,  Thuc-Huy Duong  2 ,  Van-Kieu Nguyen  3 ,  Preecha Phuwapraisirisan  3 ,  Titiruetai Doungwichitrkul  3 ,  Nakorn Niamnont  4 ,  Suekanya Jarupinthusophon  5 ,  Jirapast Sichaem  6
Affiliations
  • 1. Institute of Environment-Energy Technology, Sai Gon University, Ho Chi Minh City, Vietnam.
  • 2. Department of Chemistry, Ho Chi Minh University of Education, Ho Chi Minh City, Vietnam.
  • 3. Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.
  • 4. Organic Synthesis, Electrochemistry & Natural Product Research Unit, Department of Chemistry, Faculty of Science, King Mongkut's University of Technology Thonburi, Bangkok, Thailand.
  • 5. Program of Chemistry, Faculty of Science and Technology, Phranakhon Rajabhat University, Bangkok, Thailand.
  • 6. Faculty of Science and Technology, Thammasat University Lampang Campus, Lampang, Thailand.
PMID: 31984782 DOI: 10.1080/14786419.2020.1716351
Abstract

A novel bixanthone, named schomburgkixanthone (1), was isolated from the twigs of Garcinia schomburgkiana, along with six known compounds, griffipavixanthone (2), 4-hydroxyxanthone (3), 2-hydroxyxanthone (4), 1,6-dihydroxyxanthone (5), 1,7-dihydroxyxanthone (6), and 1,3,5-trihydroxyxanthone (7). The structure of 1 was identified by the application of NMR and MS data analyses and comparison with previous reports. Compound 1 showed the most powerful inhibition of rat intestinal α-glucosidase, with IC50 values of 0.79 for maltase and 1.81 mM for sucrase. Compound 2 most strongly inhibited sucrase, with an IC50 value of 4.58 mM.

Keywords
Garcinia schomburgkiana; Guttiferae; bixanthone; schomburgkixanthone; α-glucosidase inhibition.
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