Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora

  • J Nat Prod. 2020 Nov 25;83(11):3270-3277. doi: 10.1021/acs.jnatprod.0c00540.
Kouharu Otsuki  1 ,  Wei Li  1 ,  Kasumi Miura  1 ,  Yoshihisa Asada  1 ,  Li Huang  2 ,  Chin-Ho Chen  2 ,  Kuo-Hsiung Lee  3  4 ,  Kazuo Koike  1
Affiliations
  • 1. Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan.
  • 2. Surgical Science, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, United States.
  • 3. Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, United States.
  • 4. Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung 404, Taiwan.
PMID: 32997496 DOI: 10.1021/acs.jnatprod.0c00540
Abstract

Five new [daphneodorins D-H (1, 5, and 10-12)] and seven known daphnane Diterpenoids (2-4 and 6-9) were isolated from Daphne odora. The structures of the new compounds were elucidated by extensive physicochemical and spectroscopic analysis. The isolated compounds were evaluated for their anti-HIV activity against HIV-1 Infection of MT4 cells. Nine daphnane diterpenoid orthoesters (1-9) showed potent anti-HIV activity with EC50 values of 1.5-7.7 nM.