Caged Xanthones and Biphenyls Isolated from the Tropical Plant Garcinia lateriflora

  • J Nat Prod. 2024 Feb 23;87(2):266-275. doi: 10.1021/acs.jnatprod.3c00934.
Ayano Kobayashi  1 ,  Yohei Saito  1 ,  Katsunori Miyake  2 ,  Shuichi Fukuyoshi  1 ,  David J Newman  3 ,  Barry R O'Keefe  4  5 ,  Kuo-Hsiung Lee  6  7 ,  Kyoko Nakagawa-Goto  1  6
Affiliations
  • 1. School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-1192, Japan.
  • 2. Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan.
  • 3. NIH Special Volunteer, Wayne, Pennsylvania 19087, United States.
  • 4. Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NCI at Frederick, Frederick, Maryland 21702-1201, United States.
  • 5. Molecular Targets Program, Center for Cancer Research, National Cancer Institute, NCI at Frederick, Frederick, Maryland 21702-1201, United States.
  • 6. Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7568, United States.
  • 7. Chinese Medicine Research and Development Center, China Medical University and Hospital, 2 Yuh-Der Road, Taichung, 40447, Taiwan.
PMID: 38251859 DOI: 10.1021/acs.jnatprod.3c00934
Abstract

Four cytotoxic heptacyclic caged-xanthones [gambogefic acids B-E (1-4)], a cytotoxic hexacyclic caged-xanthone [garcilatelic acid (5)], and four biphenyl derivatives [garcilatelibiphenyls A-D (6-9)] were newly isolated in a phytochemical study of a 50% MeOH/CH2Cl2 extract of Garcinia lateriflora (Clusiaceae). The isolated compounds were evaluated for antiproliferative activity against five human tumor cell lines including a vincristine-resistant line. The new caged-xanthones displayed potent activity with IC50 values from 0.5 to 6.7 μM against all tested tumor cell lines.