Cytotoxic Polyhydroxy-Isoprenoids from Neodidymelliopsis negundinis

  • J Nat Prod. 2024 Feb 23;87(2):349-357. doi: 10.1021/acs.jnatprod.3c01094.
Patcharee Pripdeevech  1  2 ,  Sarunpron Khruengsai  1 ,  Chutima Tanapichatsakul  1 ,  Wael M Afifi  3  4 ,  Winnie Chemutai Sum  5 ,  Kevin D Hyde  1  2 ,  Sherif S Ebada  6
Affiliations
  • 1. School of Science, Mae Fah Luang University, Chiang Rai 57100, Thailand.
  • 2. Center of Chemical Innovation for Sustainability (CIS), Mae Fah Luang University, Chiang Rai 57100, Thailand.
  • 3. Department of Pharmacongosy and Medicinal Plants, Faculty of Pharmacy, Al-Azhar University, 11884 Cairo, Egypt.
  • 4. Department of Pharmacognosy, Faculty of Pharmacy, Sinai University-Kantara Branch, 41636 Ismailia, Egypt.
  • 5. Department of Biochemistry, Egerton University, P.O.536-20115 Egerton-Njoro, Kenya.
  • 6. Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Abbasia, 11566 Cairo, Egypt.
PMID: 38351796 DOI: 10.1021/acs.jnatprod.3c01094
Abstract

Fungal-derived natural products continue to play a pivotal role in the discovery of drug agents for human, veterinary, and general agricultural use. The fungus Neodidymelliopsis negundinis presents a significant saprobic ascomycete whose metabolites remained hitherto unstudied. Herein we report the isolation of eight unprecedented secondary metabolites named neodidymelliosides A and B (1 and 2), neodidymelliol A (3), and neodidymellioic acids A-E (4-8) produced by the submerged cultures of the fungus. Compound 1 proved to be the most active compound, with IC50 values ranging between 4.8 and 8.8 μM against KB3.1 (cervix), PC-3 (prostate), MCF-7 (breast), SKOV-3 (ovary), A431 (skin), and A549 (lung) cell lines. Compound 1 revealed significant inhibition of Staphylococcus aureus and Candida albicans biofilms.