Pim-1 kinase protects the liver from ischemia reperfusion injury by regulating dynamics-related protein 1

  • iScience. 2024 Jun 28;27(7):110280. doi: 10.1016/j.isci.2024.110280.
Yan-Dong Sun  1 ,  Qing-Guo Xu  1 ,  De-Shu Dai  1 ,  Shu-Xian Wang  1 ,  Xin-Qiang Li  1 ,  Shang-Heng Shi  1 ,  Peng Jiang  1 ,  Yan Jin  1 ,  Xin Wang  1 ,  Yong Zhang  1 ,  Feng Wang  1 ,  Peng Liu  1 ,  Bing-Liang Zhang  1 ,  Tian-Xiang Li  1 ,  Chuan-Shen Xu  1 ,  Bin Wu  1 ,  Jin-Zhen Cai  1
Affiliations
  • 1. Organ Transplantation Center, The Institute of Transplantation Science, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China.
PMID: 39055921 DOI: 10.1016/j.isci.2024.110280
Abstract

Hepatic ischemia-reperfusion (IR) injury significantly impacts liver transplantation success, yet current treatments remain inadequate. This study explores the role of Proto-oncogene serine/threonine-protein kinase (Pim-1) in liver IR, an area previously unexplored. Utilizing a mouse liver IR in vivo model and a MIHA cell hypoxia-reoxygenation in vitro model, we observed that Pim-1 expression increases following IR, inversely correlating with serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. Increased Pim-1 expression stabilizes mitochondrial membranes by modifying Drp1 phosphorylation, reducing mitochondrial fission and Apoptosis, thereby mitigating liver damage. Additionally, we discovered that elevated Pim-1 expression is dependent on the trimethylation of histone H3 lysine 9 during liver IR. These findings underscore the importance and potential clinical application of targeting Pim-1 in treating hepatic IR, presenting a novel therapeutic avenue.

Keywords
Cellular physiology; Endocrinology.
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