Ginger-derived nanovesicles attenuate osteoarthritis progression by inhibiting oxidative stress via the Nrf2 pathway

  • Nanomedicine (Lond). 2024;19(28):2357-2373. doi: 10.1080/17435889.2024.2403324.
Yiming Zeng  1 ,  Shun Yu  2 ,  Lin Lu  3 ,  Jun Zhang  1 ,  Chen Xu  1
Affiliations
  • 1. Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
  • 2. Department of Burns & Plastic Surgery, The Affiliated Hospital of Jiangnan University, Wuxi, 214041, China.
  • 3. Department of Plastic & Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
PMID: 39360651 DOI: 10.1080/17435889.2024.2403324
Abstract

Aim: Osteoarthritis (OA) is a common degenerative joint disease. Previous studies demonstrated ginger-derived exosome-like nanovesicles (GDN) showed therapeutic effects in degenerative diseases. However, it remains unknown whether GDN could alleviate OA progression.Materials & methods: In this study, GDN were obtained and characterized. Then we evaluated the effects of GDN in tert-butyl hydroperoxide (TBHP)-induced chondrocytes, posttraumatic OA rat model and ex vivo cultured human OA cartilage explants.Results: We demonstrated GDN promoted cartilage anabolism and alleviated oxidative stress in TBHP-induced chondrocytes and OA rat. Our results also showed GDN exhibited protective effects in cultured cartilage explants. Furthermore, we verified the Nrf2 pathway was associated with protective effects of GDN.Conclusion: Altogether, our findings demonstrated GDN hold great potential for OA treatment.

Keywords
Nrf2; ginger-derived nanovesicles; inflammation; osteoarthritis; oxidative stress.
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