Synthesis and biological evaluation of 1,2-disubstituted carbonucleosides of 2-amino-6-substituted purine and 8-azapurine

  • Bioorg Med Chem Lett. 1998 Jun 2;8(11):1349-52. doi: 10.1016/s0960-894x(98)00216-9.
L Santana  1 ,  M Teijeira ,  E Uriarte ,  J Balzarini ,  E De Clercq
Affiliations
  • 1. Laboratorio de Química Farmaceútica, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain.
PMID: 9871764 DOI: 10.1016/s0960-894x(98)00216-9
Abstract

One, two-disubstituted carbocyclic nucleoside analogues bearing a 2-amino-6-substituted (chloro, hydroxy or amino) purine or 8-azapurine base were prepared by constructing the base about (+/-)-2-aminocyclopentane methanol, and their activities against a selection of viruses and tumor cells were determined in vitro.